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DNA‐intercalative platinum anticancer complexes photoactivated by visible light
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Shi, Huayun, Kasparkova, Jana, Soulié, Clément, Clarkson, Guy J., Imberti, Cinzia, Novakova, Olga, Paterson, Martin J., Brabec, Viktor and Sadler, Peter J. (2021) DNA‐intercalative platinum anticancer complexes photoactivated by visible light. Chemistry – A European Journal, 27 (41). pp. 10711-10716. doi:10.1002/chem.202101168 ISSN 1521-3765.
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WRAP-DNA‐intercalative-platinum-anticancer-complexes-photoactivated-visible-light-Shi-2021.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (986Kb) | Preview |
Official URL: http://dx.doi.org/10.1002/chem.202101168
Abstract
Photoactivatable agents offer the prospect of highly selective cancer therapy with low side effects and novel mechanisms of action that can combat current drug resistance. 1,8-Naphthalimides with their extended π system can behave as light-harvesting groups, fluorescent probes and DNA intercalators. We conjugated N-(carboxymethyl)-1,8-naphthalimide (gly-R-Nap) with an R substituent on the naphthyl group to photoactive diazido PtIV complexes to form t,t,t-[Pt(py)2(N3)2(OH)(gly-R-Nap)], R=H (1), 3-NO2 (2) or 4-NMe2 (3). They show enhanced photo-oxidation, cellular accumulation and promising photo-cytotoxicity in human A2780 ovarian, A549 lung and PC3 prostate cancer cells with visible light activation, and low dark cytotoxicity. Complexes 1 and 2 exhibit pre-intercalation into DNA, resulting in enhanced photo-induced DNA crosslinking. Complex 3 has a red-shifted absorption band at 450 nm, allowing photoactivation and photo-cytotoxicity with green light.
Item Type: | Journal Article | |||||||||||||||||||||||||||
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Subjects: | Q Science > QD Chemistry Q Science > QH Natural history Q Science > QP Physiology R Medicine > RC Internal medicine |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | |||||||||||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Antineoplastic agents , Density functionals, DNA-drug interactions, Platinum compounds -- Therapeutic use, Cancer -- Photochemotherapy, Fluorescence spectroscopy | |||||||||||||||||||||||||||
Journal or Publication Title: | Chemistry – A European Journal | |||||||||||||||||||||||||||
Publisher: | Wiley | |||||||||||||||||||||||||||
ISSN: | 1521-3765 | |||||||||||||||||||||||||||
Official Date: | 21 July 2021 | |||||||||||||||||||||||||||
Dates: |
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Volume: | 27 | |||||||||||||||||||||||||||
Number: | 41 | |||||||||||||||||||||||||||
Page Range: | pp. 10711-10716 | |||||||||||||||||||||||||||
DOI: | 10.1002/chem.202101168 | |||||||||||||||||||||||||||
Status: | Peer Reviewed | |||||||||||||||||||||||||||
Publication Status: | Published | |||||||||||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||||||||||||||
Date of first compliant deposit: | 1 June 2021 | |||||||||||||||||||||||||||
Date of first compliant Open Access: | 2 June 2021 | |||||||||||||||||||||||||||
RIOXX Funder/Project Grant: |
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