Synthesis and anti-invasive activity of novel 1,3 -diarylpropenones
UNSPECIFIED. (1998) Synthesis and anti-invasive activity of novel 1,3 -diarylpropenones. INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 37 (7). pp. 628-643. ISSN 0376-4699Full text not available from this repository.
Thirty two novel 1,3-diarylpropenones (chalcones) have been synthesised by Claisen-Schmidt condensation. Twenty six of them are new compounds and have been fully characterised from their spectral data. The structures of five chalcones have also been confirmed by X-ray crystallography. Twenty one differently substituted chalcones have been tested against the invasion of human MCF-7/6 mammary carcinoma cells, five chalcones have been found to exhibit potent anti-invasive activity. Seven out of thirty two chalcones synthesised show herbicidal activity of interest.
|Item Type:||Journal Article|
|Subjects:||Q Science > QD Chemistry|
|Journal or Publication Title:||INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY|
|Publisher:||NATL INST SCIENCE COMMUNICATION|
|Number of Pages:||16|
|Page Range:||pp. 628-643|
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