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Chemoenzymic synthesis of beta-D-gal(6-SO4)-(1 -> 4)-D-GlcNAc, beta-D-Gal-(1 -> 4)-D-GlcNAc(6-SO4)and beta-D-GlcNAc-(1 -> 4)-D-GlcNAc(6-SO4) and their roles as fucosyl acceptors in reactions catalysed by human alpha-3-fucosyltransferases
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UNSPECIFIED (1998) Chemoenzymic synthesis of beta-D-gal(6-SO4)-(1 -> 4)-D-GlcNAc, beta-D-Gal-(1 -> 4)-D-GlcNAc(6-SO4)and beta-D-GlcNAc-(1 -> 4)-D-GlcNAc(6-SO4) and their roles as fucosyl acceptors in reactions catalysed by human alpha-3-fucosyltransferases. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 (15). pp. 2295-2299. ISSN 0300-922X
Full text not available from this repository.Abstract
N-Acetyllactosamine 5 is obtained by transglycoslyation between p-nitrophenyl beta-D-galactopyranoside 3 and N-acetyl-D-glucosamine 4 by using the beta-galactosidase from Bacillus circulans as the biocatalyst, Sodium salts of beta-Gal(6-SO4)-(1-->4)-GlcNAc 1 and beta-Gal-(1-->4)-GlcNAc(6-SO4) 2 have been prepared from N-acetyllactosamine 5 in five and three steps respectively. beta-D-GlcNAc-(1-->4)-D-GlcNAc(6-SO4) (di-N-acetylchitobiose 6-sulfate) 10 is synthesised from chitin in three steps. The products have been tested as fucosyl accepters in reactions catalysed by recombinant human fucosyltransferases III to VII.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QD Chemistry |
| Journal or Publication Title: | JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 |
| Publisher: | ROYAL SOC CHEMISTRY |
| ISSN: | 0300-922X |
| Date: | 7 August 1998 |
| Number: | 15 |
| Number of Pages: | 5 |
| Page Range: | pp. 2295-2299 |
| Publication Status: | Published |
| URI: | http://wrap.warwick.ac.uk/id/eprint/15466 |
Data sourced from Thomson Reuters' Web of Knowledge
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