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Biogenic metallic elements in the human brain?
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Everett, James, Lermyte, Frederik, Brooks, Jake, Tjendana-Tjhin, Vindy, Plascencia-Villa, G., Hands-Portman, Ian, Donnelly, Jane M., Billimoria, Kharmen, Perry, G. H., Zhu, X., Sadler, P. J., O'Connor, Peter B., Collingwood, Joanna F. and Telling, N.D. (2021) Biogenic metallic elements in the human brain? Science Advances, 7 (24). eabf6707. doi:10.1126/sciadv.abf6707
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Official URL: https://doi.org/10.1126/sciadv.abf6707
Abstract
The chemistry of copper and iron plays a critical role in normal brain function. A variety of enzymes and proteins containing positively charged Cu+, Cu2+, Fe2+, and Fe3+ control key processes, catalyzing oxidative metabolism and neurotransmitter and neuropeptide production. Here, we report the discovery of elemental (zero–oxidation state) metallic Cu0 accompanying ferromagnetic elemental Fe0 in the human brain. These nanoscale biometal deposits were identified within amyloid plaque cores isolated from Alzheimer’s disease subjects, using synchrotron x-ray spectromicroscopy. The surfaces of nanodeposits of metallic copper and iron are highly reactive, with distinctly different chemical and magnetic properties from their predominant oxide counterparts. The discovery of metals in their elemental form in the brain raises new questions regarding their generation and their role in neurochemistry, neurobiology, and the etiology of neurodegenerative disease.
| Item Type: | Journal Article | |||||||||||||||||||||||||||||||||||||||
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| Subjects: | Q Science > QP Physiology R Medicine > RC Internal medicine |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Engineering > Engineering Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) |
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| Library of Congress Subject Headings (LCSH): | Brain -- Effect of metals on, Brain chemistry , Neurobiology , Metalloproteins , Alzheimer's disease -- Molecular aspects | |||||||||||||||||||||||||||||||||||||||
| Journal or Publication Title: | Science Advances | |||||||||||||||||||||||||||||||||||||||
| Publisher: | American Association for the Advancement of Science | |||||||||||||||||||||||||||||||||||||||
| ISSN: | 2375-2548 | |||||||||||||||||||||||||||||||||||||||
| Official Date: | 9 June 2021 | |||||||||||||||||||||||||||||||||||||||
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| Volume: | 7 | |||||||||||||||||||||||||||||||||||||||
| Number: | 24 | |||||||||||||||||||||||||||||||||||||||
| Article Number: | eabf6707 | |||||||||||||||||||||||||||||||||||||||
| DOI: | 10.1126/sciadv.abf6707 | |||||||||||||||||||||||||||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||||||||||||||||||||||||||
| Publication Status: | Published | |||||||||||||||||||||||||||||||||||||||
| Access rights to Published version: | Open Access | |||||||||||||||||||||||||||||||||||||||
| RIOXX Funder/Project Grant: |
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