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Biogenic metallic elements in the human brain?

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Everett, James, Lermyte, Frederik, Brooks, Jake, Tjendana-Tjhin, Vindy, Plascencia-Villa, G., Hands-Portman, Ian, Donnelly, Jane M., Billimoria, Kharmen, Perry, G. H., Zhu, X., Sadler, P. J., O'Connor, Peter B., Collingwood, Joanna F. and Telling, N.D. (2021) Biogenic metallic elements in the human brain? Science Advances, 7 (24). eabf6707. doi:10.1126/sciadv.abf6707 ISSN 2375-2548.

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Official URL: https://doi.org/10.1126/sciadv.abf6707

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Abstract

The chemistry of copper and iron plays a critical role in normal brain function. A variety of enzymes and proteins containing positively charged Cu+, Cu2+, Fe2+, and Fe3+ control key processes, catalyzing oxidative metabolism and neurotransmitter and neuropeptide production. Here, we report the discovery of elemental (zero–oxidation state) metallic Cu0 accompanying ferromagnetic elemental Fe0 in the human brain. These nanoscale biometal deposits were identified within amyloid plaque cores isolated from Alzheimer’s disease subjects, using synchrotron x-ray spectromicroscopy. The surfaces of nanodeposits of metallic copper and iron are highly reactive, with distinctly different chemical and magnetic properties from their predominant oxide counterparts. The discovery of metals in their elemental form in the brain raises new questions regarding their generation and their role in neurochemistry, neurobiology, and the etiology of neurodegenerative disease.

Item Type: Journal Article
Subjects: Q Science > QP Physiology
R Medicine > RC Internal medicine
Divisions: Faculty of Science, Engineering and Medicine > Science > Chemistry
Faculty of Science, Engineering and Medicine > Engineering > Engineering
Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Brain -- Effect of metals on, Brain chemistry , Neurobiology , Metalloproteins , Alzheimer's disease -- Molecular aspects
Journal or Publication Title: Science Advances
Publisher: American Association for the Advancement of Science
ISSN: 2375-2548
Official Date: 9 June 2021
Dates:
DateEvent
9 June 2021Published
22 April 2021Accepted
Volume: 7
Number: 24
Article Number: eabf6707
DOI: 10.1126/sciadv.abf6707
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 29 June 2021
Date of first compliant Open Access: 6 July 2021
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
EP/K035193/1, [EPSRC] Engineering and Physical Sciences Research Councilhttp://dx.doi.org/10.13039/501100000266
R01AG066749National Institutes of Healthhttp://dx.doi.org/10.13039/100000002
AARFD-17-529742Alzheimer's Associationhttp://dx.doi.org/10.13039/100000957
EP/N033191/1[EPSRC] Engineering and Physical Sciences Research Councilhttp://dx.doi.org/10.13039/501100000266
EP/N033140/1[EPSRC] Engineering and Physical Sciences Research Councilhttp://dx.doi.org/10.13039/501100000266
EP/P030572/1[EPSRC] Engineering and Physical Sciences Research Councilhttp://dx.doi.org/10.13039/501100000266
EP/L015307/1[EPSRC] Engineering and Physical Sciences Research Councilhttp://dx.doi.org/10.13039/501100000266
EP/N509796/1 [EPSRC] Engineering and Physical Sciences Research Councilhttp://dx.doi.org/10.13039/501100000266
UNSPECIFIEDUniversity of Warwickhttp://dx.doi.org/10.13039/501100000741
UNSPECIFIEDRobert J. Kleberg, Jr. and Helen C. Kleberg Foundationhttp://dx.doi.org/10.13039/100012394
UNSPECIFIEDEdward Lowe Foundationhttp://dx.doi.org/10.13039/100003924
UNSPECIFIEDSemmes Foundationhttp://semmesfoundation.org/
Is Part Of: 1
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