The Library
Aberrant claustrum microstructure in humans after premature birth
Tools
Hedderich, Dennis M., Menegaux, Aurore, Li, Hongwei, Schmitz-Koep, Benita, Stämpfli, Philipp, Bäuml, Josef G., Berndt, Maria T., Bäuerlein, Felix J. B., Grothe, Michel J., Dyrba, Martin, Avram, Mihai, Boecker, Henning, Daamen, Marcel, Zimmer, Claus, Bartmann, Peter, Wolke, Dieter and Sorg, Christian (2021) Aberrant claustrum microstructure in humans after premature birth. Cerebral Cortex, 31 (12). pp. 5549-5559. doi:10.1093/cercor/bhab178 ISSN 1460-2199.
|
PDF
WRAP-Aberrant-claustrum-microstructure-humans-premature-birth-2021.pdf - Accepted Version - Requires a PDF viewer. Download (450Kb) | Preview |
Official URL: https://doi.org/10.1093/cercor/bhab178
Abstract
Several observations suggest an impact of prematurity on the claustrum. First, the claustrum’s development appears to depend on transient subplate neurons of intra-uterine brain development, which are affected by prematurity. Second, the claustrum is the most densely connected region of the mammalian forebrain relative to its volume; due to its effect on pre-oligodendrocytes, prematurity impacts white matter connections and thereby the development of sources and targets of such connections, potentially including the claustrum. Third, due to its high connection degree, the claustrum contributes to general cognitive functioning (e.g., selective attention and task switching/maintaining); general cognitive functioning, however, is at risk in prematurity. Thus, we hypothesized altered claustrum structure after premature birth, with these alterations being associated with impaired general cognitive performance in premature born persons. Using T1-weighted and diffusion-weighted magnetic resonance imaging in 70 very preterm/very low-birth-weight (VP/VLBW) born adults and 87 term-born adults, we found specifically increased mean diffusivity in the claustrum of VP/VLBW adults, associated both with low birth weight and at-trend with reduced IQ. This result demonstrates altered claustrum microstructure after premature birth. Data suggest aberrant claustrum development, which is potentially related with aberrant subplate neuron and forebrain connection development of prematurity.
Item Type: | Journal Article | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Subjects: | Q Science > QP Physiology R Medicine > RC Internal medicine R Medicine > RJ Pediatrics |
||||||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Science > Psychology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
||||||||||||||||||
SWORD Depositor: | Library Publications Router | ||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Claustrum, Premature infants, Premature infants -- Development, Premature infants -- Intelligence levels, Cognition disorders, Magnetic resonance imaging , Brain -- Magnetic resonance imaging | ||||||||||||||||||
Journal or Publication Title: | Cerebral Cortex | ||||||||||||||||||
Publisher: | Oxford University Press (OUP) | ||||||||||||||||||
ISSN: | 1460-2199 | ||||||||||||||||||
Official Date: | December 2021 | ||||||||||||||||||
Dates: |
|
||||||||||||||||||
Volume: | 31 | ||||||||||||||||||
Number: | 12 | ||||||||||||||||||
Page Range: | pp. 5549-5559 | ||||||||||||||||||
DOI: | 10.1093/cercor/bhab178 | ||||||||||||||||||
Status: | Peer Reviewed | ||||||||||||||||||
Publication Status: | Published | ||||||||||||||||||
Reuse Statement (publisher, data, author rights): | This is a pre-copyedited, author-produced version of an article accepted for publication in Cerebral Cortex following peer review. The version of record Dennis M Hedderich, Aurore Menegaux, Hongwei Li, Benita Schmitz-Koep, Philipp Stämpfli, Josef G Bäuml, Maria T Berndt, Felix J B Bäuerlein, Michel J Grothe, Martin Dyrba, Mihai Avram, Henning Boecker, Marcel Daamen, Claus Zimmer, Peter Bartmann, Dieter Wolke, Christian Sorg, Aberrant Claustrum Microstructure in Humans after Premature Birth, Cerebral Cortex, Volume 31, Issue 12, December 2021, Pages 5549–5559, is available online at: https://doi.org/10.1093/cercor/bhab178 | ||||||||||||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||||||||||||
Date of first compliant deposit: | 25 August 2021 | ||||||||||||||||||
Date of first compliant Open Access: | 25 June 2022 | ||||||||||||||||||
RIOXX Funder/Project Grant: |
|
||||||||||||||||||
Related URLs: |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |
Downloads
Downloads per month over past year