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35 Cl ‐ 1 H heteronuclear correlation MAS NMR experiments for probing pharmaceutical salts

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Iuga, Dinu, Corlett, Emily K. and Brown, Steven P. (2021) 35 Cl ‐ 1 H heteronuclear correlation MAS NMR experiments for probing pharmaceutical salts. Magnetic Resonance in Chemistry, 59 (9-10). pp. 1089-1100. doi:10.1002/mrc.5188 ISSN 0749-1581.

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Official URL: http://dx.doi.org/10.1002/mrc.5188

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Abstract

Heteronuclear multiple-quantum coherence (HMQC) pulse sequences for establishing heteronuclear correlation in solid-state NMR between 35Cl and 1H atoms in chloride salts under fast (60 kHz) magic-angle spinning (MAS) and at high magnetic field (a 1H Larmor frequency of 850 MHz) are investigated. Specifically, recoupling of the 35Cl - 1H dipolar interaction using rotary resonance recoupling with phase inversion every rotor period or the symmetry based SR421 pulse sequence are compared. In our implementation of the PT (population-transfer)-D-HMQC experiment, the satellite transitions of the 35Cl nuclei are saturated with an off-resonance WURST sweep, at a low nutation frequency, over the second spinning sideband, whereby the WURST pulse must be of the same duration as the recoupling time. Numerical simulations of the 35Cl - 1H MAS D-HMQC experiment performed separately for each crystallite orientation in a powder provide insight into the orientation dependence of changes in the second-order quadrupolar broadened 35Cl MAS NMR lineshape under the application of dipolar recoupling. Two-dimensional 35Cl - 1H PT-D-HMQC MAS NMR spectra are presented for the amino acids glycine·HCl and L-tyrosine·HCl and the pharmaceuticals cimetidine·HCl, amitriptyline·HCl and lidocaine·HCl·H2O. Experimentally observed 35Cl lineshapes are compared with those simulated for 35Cl chemical shift and quadrupolar parameters as calculated using the gauge-including projector-augmented wave (GIPAW) method: the calculated quadrupolar product (PQ) values exceed those measured experimentally by a factor of between 1.3 and 1.9.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science, Engineering and Medicine > Science > Physics
Library of Congress Subject Headings (LCSH): Chlorides, Hydrochloric acid, Nuclear magnetic resonance spectroscopy, Nuclear magnetic resonance, Pharmaceutical chemistry, Crystallization
Journal or Publication Title: Magnetic Resonance in Chemistry
Publisher: John Wiley & Sons Ltd.
ISSN: 0749-1581
Official Date: September 2021
Dates:
DateEvent
September 2021Published
1 July 2021Available
26 June 2021Accepted
Volume: 59
Number: 9-10
Page Range: pp. 1089-1100
DOI: 10.1002/mrc.5188
Status: Peer Reviewed
Publication Status: Published
Reuse Statement (publisher, data, author rights): This is the peer reviewed version of the following article: Iuga, D, Corlett, EK, Brown, SP. 35Cl - 1H Heteronuclear Correlation MAS NMR Experiments for Probing Pharmaceutical Salts. Magn Reson Chem. 2021., which has been published in final form at https://doi.org/10.1002/mrc.5188. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 6 July 2021
Date of first compliant Open Access: 21 July 2021
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
EP/T015063/1[EPSRC] Engineering and Physical Sciences Research Councilhttp://dx.doi.org/10.13039/501100000266
PR140003[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
EP/L015307/1[EPSRC] Engineering and Physical Sciences Research Councilhttp://dx.doi.org/10.13039/501100000266
UNSPECIFIEDUniversity of Warwickhttp://dx.doi.org/10.13039/501100000741
UNSPECIFIEDAdvantage West Midlandshttp://dx.doi.org/10.13039/100014381
UNSPECIFIEDScience City Research AllianceUNSPECIFIED
UNSPECIFIED[ERDF] European Regional Development Fundhttp://dx.doi.org/10.13039/501100008530
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