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An electronic health record approach to understanding drug to drug interactions and associated knowledge gaps in intergrated care of multimorbidity

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Despotou, George and Arvanitis, Theodoros N. (2021) An electronic health record approach to understanding drug to drug interactions and associated knowledge gaps in intergrated care of multimorbidity. In: Mantas, John and Lăcrămioara, Stoicu-Tivadar and Chronaki, Catherine and Hasman, Arie and Weber, Patrick and Gallos, Parisis and Crişan-Vida, Mihaela and Zoulias, Emmanouil and Sorina Chirila, Oana, (eds.) Public Health and Informatics. Studies in Health Technology and Informatics, 281 . IOS Press, pp. 580-584. ISBN 9781643681849

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Official URL: http://dx.doi.org/10.3233/SHTI210237

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Abstract

Multimorbid patients are prescribed a number of medications in parallel, which may often interact with each other, resulting in adverse effects. However, clinical guidelines on prescription of medications predominantly focus on individual conditions do not consider the guidance in the context of other guidelines, resulting in conflicts. C3-Cloud is an integrated care architecture managing multimorbidity, which amongst others, provides clinical decision support, based on reconciled guidelines, and active monitoring of drug interactions. To identify the severe interactions that resulted from multimorbidity management, in order to reevaluate guidelines as well as to identify knowledge gaps in prescribing practice. Method: Descriptive statistical analysis of interactions identified by the C3-Cloud clinical decision support, collected from the C3-Cloud FHIR repository. As part of a feasibility study, a number of interactions were identified, along with variable practice in how chemicals are represented in the EHR. 191 known severe interactions were identified. The Atorvastatin/Verapamil interaction was the most frequent. The approach has identified a number of interactions where the severity was not available, highlighting the need for further clinical review.

Item Type: Book Item
Subjects: R Medicine > RA Public aspects of medicine
Divisions: Faculty of Science > WMG (Formerly the Warwick Manufacturing Group)
Library of Congress Subject Headings (LCSH): Patients -- Safety measures, Health services administration -- Data processing, Medical care -- Safety measures, Drug interactions, Drugs -- Side effects, Medical records -- Data processing, Clinical medicine -- Decision making -- Data processing
Series Name: Studies in Health Technology and Informatics
Publisher: IOS Press
ISBN: 9781643681849
ISSN: 09269630
Book Title: Public Health and Informatics
Editor: Mantas, John and Lăcrămioara, Stoicu-Tivadar and Chronaki, Catherine and Hasman, Arie and Weber, Patrick and Gallos, Parisis and Crişan-Vida, Mihaela and Zoulias, Emmanouil and Sorina Chirila, Oana
Official Date: 2021
Dates:
DateEvent
2021Published
19 April 2021Accepted
Volume: 281
Page Range: pp. 580-584
DOI: 10.3233/SHTI210237
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
689181[ERC] Horizon 2020 Framework Programmehttp://dx.doi.org/10.13039/100010661

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