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4D polycarbonates via stereolithography as scaffolds for soft tissue repair
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Weems, Andrew C., Arno, Maria C., Yue, Wei, Huckstepp, Robert T. R. and Dove, Andrew P. (2021) 4D polycarbonates via stereolithography as scaffolds for soft tissue repair. Nature Communications, 12 (1). 3771. doi:10.1038/s41467-021-23956-6 ISSN 2041-1723.
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WRAP-4D-polycarbonates-via-stereolithography-scaffolds-soft-tissue-repair-Huckstepp-2021.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (4Mb) | Preview |
Official URL: http://dx.doi.org/10.1038/s41467-021-23956-6
Abstract
3D printing has emerged as one of the most promising tools to overcome the processing and morphological limitations of traditional tissue engineering scaffold design. However, there is a need for improved minimally invasive, void-filling materials to provide mechanical support, biocompatibility, and surface erosion characteristics to ensure consistent tissue support during the healing process. Herein, soft, elastomeric aliphatic polycarbonate-based materials were designed to undergo photopolymerization into supportive soft tissue engineering scaffolds. The 4D nature of the printed scaffolds is manifested in their shape memory properties, which allows them to fill model soft tissue voids without deforming the surrounding material. In vivo, adipocyte lobules were found to infiltrate the surface-eroding scaffold within 2 months, and neovascularization was observed over the same time. Notably, reduced collagen capsule thickness indicates that these scaffolds are highly promising for adipose tissue engineering and repair.
| Item Type: | Journal Article | ||||||||||||
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| Subjects: | Q Science > QD Chemistry R Medicine > R Medicine (General) T Technology > TP Chemical technology T Technology > TS Manufactures |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||||||
| Library of Congress Subject Headings (LCSH): | Three-dimensional printing , Polycarbonates , Rapid prototyping , Biomedical engineering, Tissue engineering, Photopolymerization | ||||||||||||
| Journal or Publication Title: | Nature Communications | ||||||||||||
| Publisher: | Nature Publishing Group | ||||||||||||
| ISSN: | 2041-1723 | ||||||||||||
| Official Date: | 5 July 2021 | ||||||||||||
| Dates: |
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| Volume: | 12 | ||||||||||||
| Number: | 1 | ||||||||||||
| Article Number: | 3771 | ||||||||||||
| DOI: | 10.1038/s41467-021-23956-6 | ||||||||||||
| Status: | Peer Reviewed | ||||||||||||
| Publication Status: | Published | ||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||
| Date of first compliant deposit: | 7 July 2021 | ||||||||||||
| Date of first compliant Open Access: | 8 July 2021 | ||||||||||||
| RIOXX Funder/Project Grant: |
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| Is Part Of: | 1 |
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