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Orbitofrontal cortex connectivity is associated with food reward and body weight in humans

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Rolls, Edmund T., Feng, Ruiqing, Cheng, Wei and Feng, Jianfeng (2021) Orbitofrontal cortex connectivity is associated with food reward and body weight in humans. Social Cognitive and Affective Neuroscience . nsab083. doi:10.1093/scan/nsab083 (In Press)

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Official URL: https://doi.org/10.1093/scan/nsab083

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Abstract

The aim was to investigate with very large scale analyses whether there are underlying functional connectivity differences between humans that relate to food reward; and whether these in turn are associated with being overweight. In 37,286 humans from the UK Biobank resting state functional connectivities of the orbitofrontal cortex, especially with the anterior cingulate cortex, were positively correlated with the liking for sweet foods (FDR p < 0.05). They were also positively correlated with the body mass index (BMI) (FDR p < 0.05). Moreover, in a sample of 502,492 people, the 'liking for sweet foods' was correlated with their BMI (r=0.06, p<10-125). In a cross-validation with 545 participants from the Human Connectome Project, higher functional connectivity involving the orbitofrontal cortex relative to other brain areas was associated with high BMI (≥30) compared to a mid-BMI group (22-25; p=6x10-5); and low orbitofrontal cortex functional connectivity was associated with low BMI (≤20.5; p<0.024). It is proposed that high BMI relates to increased efficacy of orbitofrontal cortex food reward systems, and low BMI to decreased efficacy. This was found with no stimulation by food, so may be an underlying individual difference in brain connectivity that is related to food reward and BMI. [Abstract copyright: © The Author(s) 2021. Published by Oxford University Press.]

Item Type: Journal Article
Subjects: Q Science > QP Physiology
R Medicine > RC Internal medicine
T Technology > TX Home economics
Divisions: Faculty of Science > Computer Science
SWORD Depositor: Library Publications Router
Library of Congress Subject Headings (LCSH): Prefrontal cortex, Food habits -- Psychological aspects , Obesity -- Molecular aspects, Brain -- Localization of functions, Body mass index , Cognitive neuroscience
Journal or Publication Title: Social Cognitive and Affective Neuroscience
Publisher: Oxford University Press
ISSN: 1749-5024
Official Date: 14 July 2021
Dates:
DateEvent
14 July 2021Available
29 June 2021Accepted
Article Number: nsab083
DOI: 10.1093/scan/nsab083
Status: Peer Reviewed
Publication Status: In Press
Access rights to Published version: Restricted or Subscription Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
15JC1400101Shanghai Science and Technology Development Foundationhttp://dx.doi.org/10.13039/100012543
16JC1420402Shanghai Science and Technology Development Foundationhttp://dx.doi.org/10.13039/100012543
71661167002[NSFC] National Natural Science Foundation of Chinahttp://dx.doi.org/10.13039/501100001809
91630314[NSFC] National Natural Science Foundation of Chinahttp://dx.doi.org/10.13039/501100001809
B18015Higher Education Discipline Innovation Projecthttp://dx.doi.org/10.13039/501100013314
2018SHZDZX01Science and Technology Commission of Shanghai Municipalityhttp://dx.doi.org/10.13039/501100003399
81701773[NSFC] National Natural Science Foundation of Chinahttp://dx.doi.org/10.13039/501100001809
11771010[NSFC] National Natural Science Foundation of Chinahttp://dx.doi.org/10.13039/501100001809
18ZR1404400Natural Science Foundation of Shanghaihttp://dx.doi.org/10.13039/100007219

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