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Overlapping functions of components of a bacterial Sec-independent protein export pathway
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UNSPECIFIED (1998) Overlapping functions of components of a bacterial Sec-independent protein export pathway. EMBO JOURNAL, 17 (13). pp. 3640-3650. ISSN 0261-4189
Full text not available from this repository.Abstract
We describe the identification of two Escherichia coli genes required for the export of cofactor-containing periplasmic proteins, synthesized with signal peptides containing a twin arginine motif, Both gene products are homologous to the maize HCF106 protein required for the translocation of a subset of lumenal proteins across the thylakoid membrane. Disruption of either gene affects the export of a range of such proteins, and a complete block is observed when both genes are inactivated. The Sec protein export pathway was unaffected, indicating the involvement of the gene products in a novel export system. The accumulation of active cofactor-containing proteins in the cytoplasm of the mutant strains suggests a role for the gene products in the translocation of folded proteins. One of the two HCF106 homologues is encoded by the first gene of a four cistron operon, tatABCD, and the second by an unlinked gene, tatE, A mutation previously assigned to the hcf106 homologue encoded at the tatABCD locus, mttA, lies instead in the tatB gene.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
| Journal or Publication Title: | EMBO JOURNAL |
| Publisher: | OXFORD UNIV PRESS |
| ISSN: | 0261-4189 |
| Date: | 1 July 1998 |
| Volume: | 17 |
| Number: | 13 |
| Number of Pages: | 11 |
| Page Range: | pp. 3640-3650 |
| Publication Status: | Published |
| URI: | http://wrap.warwick.ac.uk/id/eprint/15570 |
Data sourced from Thomson Reuters' Web of Knowledge
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