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A prion-like protein regulator of seed germination undergoes hydration-dependent phase separation
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Dorone, Yanniv, Boeynaems, Steven, Flores, Eduardo, Jin, Benjamin, Hateley, Shannon, Bossi, Flavia, Lazarus, Elena, Pennington, Janice G., Michiels, Emiel, De Decker, Mathias, Vints, Katlijn, Baatsen, Pieter, Bassel, George, Otegui, Marisa S., Holehouse, Alex S., Exposito-Alonso, Moises, Sukenik, Shahar, Gitler, Aaron D. and Rhee, Seung Y. (2021) A prion-like protein regulator of seed germination undergoes hydration-dependent phase separation. Cell, 184 (16). 4284-4298.e27. doi:10.1016/j.cell.2021.06.009 ISSN 0092-8674.
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Official URL: https://doi.org/10.1016/j.cell.2021.06.009
Abstract
Many organisms evolved strategies to survive desiccation. Plant seeds protect dehydrated embryos from various stressors and can lay dormant for millennia. Hydration is the key trigger to initiate germination, but the mechanism by which seeds sense water remains unresolved. We identified an uncharacterized Arabidopsis thaliana prion-like protein we named FLOE1, which phase separates upon hydration and allows the embryo to sense water stress. We demonstrate that biophysical states of FLOE1 condensates modulate its biological function in vivo in suppressing seed germination under unfavorable environments. We find intragenic, intraspecific, and interspecific natural variation in FLOE1 expression and phase separation and show that intragenic variation is associated with adaptive germination strategies in natural populations. This combination of molecular, organismal, and ecological studies uncovers FLOE1 as a tunable environmental sensor with direct implications for the design of drought-resistant crops, in the face of climate change. [Abstract copyright: Copyright © 2021 Elsevier Inc. All rights reserved.]
Item Type: | Journal Article | ||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||
SWORD Depositor: | Library Publications Router | ||||||||
Journal or Publication Title: | Cell | ||||||||
Publisher: | Cell Press | ||||||||
ISSN: | 0092-8674 | ||||||||
Official Date: | 5 August 2021 | ||||||||
Dates: |
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Volume: | 184 | ||||||||
Number: | 16 | ||||||||
Page Range: | 4284-4298.e27 | ||||||||
DOI: | 10.1016/j.cell.2021.06.009 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) |
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