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Growth in extremely preterm children born in England in 1995 and 2006 : the EPICure studies
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Ni, Yanyan, Lancaster, Rebecca, Suonpera, Emmi, Bernardi, Marialivia, Fahy, Amanda, Larsen, Jennifer, Trickett, Jayne, Hurst, John R., Wolke, Dieter, Johnson, Samantha and Marlow, Neil (2021) Growth in extremely preterm children born in England in 1995 and 2006 : the EPICure studies. Archives of Disease in Childhood - Fetal and Neonatal Edition . doi:10.1136/archdischild-2020-321107 (In Press)
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WRAP-growth-extremely-preterm-children-born-England-1995-2006-Wolke-2021.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (502Kb) | Preview |
Official URL: https://doi.org/10.1136/archdischild-2020-321107
Abstract
Objectives: To determine growth outcomes at 11 years of age in children born <27 weeks of gestation in England in 2006 (EPICure2) and to compare growth from birth to 11 years of age for births<26 weeks with those in England in 1995 (EPICure).
Methods: 200 EPICure2 children assessed at 11 years alongside 143 term-born controls. Growth measures from birth to 11 years were compared for births<26 weeks between EPICure2 (n=112) and EPICure (n=176). Growth parameter z-scores were derived from 1990 UK standards.
Results: Among EPICure2 children, mean z-scores for height and weight were close to the population standards (0.08 and 0.18 SD, respectively) but significantly below those of controls: difference in mean (Δ) z-scores for weight −0.42 SD (95% CI −0.68 to –0.17), for height −0.45 SD (−0.70 to –0.20) and for head circumference (HC) −1.05 SD (−1.35 to –0.75); mean body mass index (BMI) z-score in EPICure2 children was 0.18 SD, not significantly different from controls (0.43 SD, p=0.065). Compared with EPICure, EPICure2 children born <26 weeks at 11 years had higher z-scores for weight (Δ 0.72 (0.47, 0.96)), height (Δ 0.55 (0.29, 0.81)) and BMI (Δ 0.56 (0.24, 0.87)), which were not fully explained by perinatal/demographic differences between eras. Weight catch-up was greater from term-age to 2.5/3 years in EPICure2 than in EPICure (1.25 SD vs 0.53 SD; p<0.001). Poor HC growth was observed in EPICure2, unchanged from EPICure.
Conclusions: Since 1995, childhood growth in weight, height and BMI have improved for births <26 weeks of gestation, but there was no improvement in head growth.
| Item Type: | Journal Article | |||||||||
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| Subjects: | R Medicine > RJ Pediatrics | |||||||||
| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science > Psychology Faculty of Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Children -- Growth, Prematurely born children -- England | |||||||||
| Journal or Publication Title: | Archives of Disease in Childhood - Fetal and Neonatal Edition | |||||||||
| Publisher: | B M J Group | |||||||||
| ISSN: | 1359-2998 | |||||||||
| Official Date: | 13 July 2021 | |||||||||
| Dates: |
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| DOI: | 10.1136/archdischild-2020-321107 | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | In Press | |||||||||
| Access rights to Published version: | Open Access | |||||||||
| RIOXX Funder/Project Grant: |
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