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Growth in extremely preterm children born in England in 1995 and 2006 : the EPICure studies

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Ni, Yanyan, Lancaster, Rebecca, Suonpera, Emmi, Bernardi, Marialivia, Fahy, Amanda, Larsen, Jennifer, Trickett, Jayne, Hurst, John R., Wolke, Dieter, Johnson, Samantha and Marlow, Neil (2022) Growth in extremely preterm children born in England in 1995 and 2006 : the EPICure studies. Archives of Disease in Childhood - Fetal and Neonatal Edition, 107 (2). pp. 193-200. doi:10.1136/archdischild-2020-321107

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Official URL: https://doi.org/10.1136/archdischild-2020-321107

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Abstract

Objectives: To determine growth outcomes at 11 years of age in children born <27 weeks of gestation in England in 2006 (EPICure2) and to compare growth from birth to 11 years of age for births<26 weeks with those in England in 1995 (EPICure).

Methods: 200 EPICure2 children assessed at 11 years alongside 143 term-born controls. Growth measures from birth to 11 years were compared for births<26 weeks between EPICure2 (n=112) and EPICure (n=176). Growth parameter z-scores were derived from 1990 UK standards.

Results: Among EPICure2 children, mean z-scores for height and weight were close to the population standards (0.08 and 0.18 SD, respectively) but significantly below those of controls: difference in mean (Δ) z-scores for weight −0.42 SD (95% CI −0.68 to –0.17), for height −0.45 SD (−0.70 to –0.20) and for head circumference (HC) −1.05 SD (−1.35 to –0.75); mean body mass index (BMI) z-score in EPICure2 children was 0.18 SD, not significantly different from controls (0.43 SD, p=0.065). Compared with EPICure, EPICure2 children born <26 weeks at 11 years had higher z-scores for weight (Δ 0.72 (0.47, 0.96)), height (Δ 0.55 (0.29, 0.81)) and BMI (Δ 0.56 (0.24, 0.87)), which were not fully explained by perinatal/demographic differences between eras. Weight catch-up was greater from term-age to 2.5/3 years in EPICure2 than in EPICure (1.25 SD vs 0.53 SD; p<0.001). Poor HC growth was observed in EPICure2, unchanged from EPICure.

Conclusions: Since 1995, childhood growth in weight, height and BMI have improved for births <26 weeks of gestation, but there was no improvement in head growth.

Item Type: Journal Article
Subjects: R Medicine > RJ Pediatrics
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing
Faculty of Science, Engineering and Medicine > Science > Psychology
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Children -- Growth, Prematurely born children -- England
Journal or Publication Title: Archives of Disease in Childhood - Fetal and Neonatal Edition
Publisher: B M J Group
ISSN: 1359-2998
Official Date: 17 February 2022
Dates:
DateEvent
17 February 2022Published
13 July 2021Available
28 June 2021Accepted
Volume: 107
Number: 2
Page Range: pp. 193-200
DOI: 10.1136/archdischild-2020-321107
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
MR/N024869/1Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
UNSPECIFIEDNIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Researchhttp://dx.doi.org/10.13039/100014461

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