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Seeking insights into aging through yeast mitochondrial electrophysiology

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de Souza-Guerreiro, Tailise Carolina and Asally, Munehiro (2021) Seeking insights into aging through yeast mitochondrial electrophysiology. Bioelectricity, 3 (2). pp. 111-115. doi:10.1089/bioe.2021.0011 ISSN 2576-3105.

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Official URL: https://doi.org/10.1089/bioe.2021.0011

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Abstract

During aging, mitochondrial membrane potential, a key indicator for bioenergetics of cells, depolarizes in a wide range of species—from yeasts, plants to animals. In humans, the decline of mitochondrial activities can impact the high-energy-consuming organs, such as the brain and heart, and increase the risks of age-linked diseases. Intriguingly, a mild depolarization of mitochondria has lifespan-extending effects, suggesting an important role played by bioelectricity during aging. However, the underpinning biophysical mechanism is not very well understood due in part to the difficulties associated with a multiscale process. Budding yeast Saccharomyces cerevisiae could provide a model system to bridge this knowledge gap and provide insights into aging. In this perspective, we overview recent studies on the yeast mitochondrial membrane electrophysiology and aging and call for more electrochemical and biophysical studies on aging.

Item Type: Journal Article
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QK Botany
Q Science > QP Physiology
Divisions: Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Aging, Mitochondrial membranes, Electrophysiology, Saccharomyces cerevisiae
Journal or Publication Title: Bioelectricity
Publisher: Mary Ann Liebert
ISSN: 2576-3105
Official Date: June 2021
Dates:
DateEvent
June 2021Published
16 June 2021Available
1 June 2021Accepted
Volume: 3
Number: 2
Page Range: pp. 111-115
DOI: 10.1089/bioe.2021.0011
Status: Peer Reviewed
Publication Status: Published
Reuse Statement (publisher, data, author rights): Final publication is available from Mary Ann Liebert, Inc., publishers http://dx.doi.org/10.1089/bioe.2021.0011
Access rights to Published version: Restricted or Subscription Access
Date of first compliant deposit: 22 July 2021
Date of first compliant Open Access: 16 June 2022
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
BB/M017982/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
BB/M017982/1[EPSRC] Engineering and Physical Sciences Research Councilhttp://dx.doi.org/10.13039/501100000266
Is Part Of: 1

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