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Bioluminescent imaging in induced mouse models of endometriosis reveals differences in four model variations

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Dorning, Ashley, Dhami, Priya, Panir, Kavita, Hogg, Chloe, Park, Emma, Ferguson, Gregory D., Hargrove, Diane, Karras, James, Horne, Andrew W. and Greaves, Erin (2021) Bioluminescent imaging in induced mouse models of endometriosis reveals differences in four model variations. Disease Models and Mechanisms, 14 (8). dmm049070. doi:10.1242/dmm.049070

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Official URL: https://doi.org/10.1242/dmm.049070

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Abstract

Our understanding of the etiology and pathophysiology of endometriosis remains limited. Disease modelling in the field is problematic as many versions of induced mouse models of endometriosis exist. We integrated bioluminescent imaging of ‘lesions’ generated using luciferase-expressing donor mice. We compared longitudinal bioluminescence and histology of lesions, sensory behavior of mice with induced endometriosis and the impact of the GnRH antagonist Cetrorelix on lesion regression and sensory behavior. Four models of endometriosis were tested. We found that the nature of the donor uterine material was a key determinant of how chronic the lesions were as well as their cellular composition. The severity of pain-like behavior also varied across models. Whilst Cetrorelix significantly reduced lesion bioluminescence in all models, it had varying impacts on pain-like behavior. Collectively, our results demonstrate key differences in the progression of the ‘disease’ across different mouse models of endometriosis. We propose that validation and testing in multiple models, each of which may be representative of the different subtypes / heterogeneity observed in women should become a standard approach to discovery science in the field of endometriosis.

Item Type: Journal Article
Alternative Title:
Subjects: R Medicine > RG Gynecology and obstetrics
Divisions: Faculty of Medicine > Warwick Medical School > Biomedical Sciences
Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Endometriosis -- Etiology -- Research, Bioluminescence, Imaging systems in biology -- Methodology
Journal or Publication Title: Disease Models and Mechanisms
Publisher: The Company of Biologists
ISSN: 1754-8403
Official Date: 12 August 2021
Dates:
DateEvent
12 August 2021Published
21 July 2021Accepted
Volume: 14
Number: 8
Article Number: dmm049070
DOI: 10.1242/dmm.049070
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
MR/M009238/1[MRC] Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
R42533Wellbeing of Womenhttp://dx.doi.org/10.13039/501100000325
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