Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Auditory brainstem measures and genotyping boost the prediction of literacy : a longitudinal study on early markers of dyslexia

Tools
- Tools
+ Tools

LEGASCREEN Consortium (Including: Liebig, Johanna, Friederici, Angela D., Neef, Nicole E., Friederici, A. D., Emmrich, F., Brauer, J., Wilcke, A., Neef, N. E., Boltze, Johannes, Skeide, M., Kirsten, H., Schaadt, G., Müller, B., Kraft, I., Czepezauer, I. and Dörr, L.). (2020) Auditory brainstem measures and genotyping boost the prediction of literacy : a longitudinal study on early markers of dyslexia. Developmental Cognitive Neuroscience, 46 . 100869. doi:10.1016/j.dcn.2020.100869

[img]
Preview
PDF
WRAP-Auditory-brainstem-measures-genotyping-boost-literacy-dyslexia-2021.pdf - Published Version - Requires a PDF viewer.
Available under License Creative Commons Attribution 4.0.

Download (2653Kb) | Preview
Official URL: http://dx.doi.org/10.1016/j.dcn.2020.100869

Request Changes to record.

Abstract

Literacy acquisition is impaired in children with developmental dyslexia resulting in lifelong struggle to read and spell. Proper diagnosis is usually late and commonly achieved after structured schooling started, which causes delayed interventions. Legascreen set out to develop a preclinical screening to identify children at risk of developmental dyslexia. To this end we examined 93 preliterate German children, half of them with a family history of dyslexia and half of them without a family history. We assessed standard demographic and behavioral precursors of literacy, acquired saliva samples for genotyping, and recorded speech-evoked brainstem responses to add an objective physiological measure. Reading and spelling was assessed after two years of structured literacy instruction. Multifactorial regression analyses considering demographic information, genotypes, and auditory brainstem encoding, predicted children’s literacy skills to varying degrees. These predictions were improved by adding the standard psychometrics with a slightly higher impact on spelling compared to reading comprehension. Our findings suggest that gene-brain-behavior profiling has the potential to determine the risk of developmental dyslexia. At the same time our results imply the need for a more sophisticated assessment to fully account for the disparate cognitive profiles and the multifactorial basis of developmental dyslexia.

Item Type: Journal Article
Subjects: R Medicine > RJ Pediatrics
Divisions: Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Dyslexia, Dyslexia -- Genetic aspects, Auditory perception, Auditory perception in children, Language disorders in children, Reading disability
Journal or Publication Title: Developmental Cognitive Neuroscience
Publisher: Elsevier
ISSN: 1878-9293
Official Date: December 2020
Dates:
DateEvent
December 2020Published
7 October 2020Available
20 September 2020Accepted
Volume: 46
Article Number: 100869
DOI: 10.1016/j.dcn.2020.100869
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
Description:

Erratum to “Auditory brainstem measures and genotyping boost the prediction of literacy: A longitudinal study on early markers of dyslexia” [Dev. Cognit. Neurosci. 46 (2020) 100869]
Developmental Cognitive Neuroscience, Volume 48, April 2021, Pages 100889

RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
UNSPECIFIEDMax-Planck-Gesellschafthttp://dx.doi.org/10.13039/501100004189
M.FE.A.NEPF0001Fraunhofer-Gesellschafthttp://dx.doi.org/10.13039/501100003185

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics

twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us