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Manipulating the microbiome : an alternative treatment for bile acid diarrhoea

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Hillman, Evette B. M, Rijpkema, Sjoerd, Carson, Danielle, Arasaradnam, Ramesh P., Wellington, Elizabeth M. H. and Amos, Gregory C. A. (2021) Manipulating the microbiome : an alternative treatment for bile acid diarrhoea. Microbiology Research, 12 (2). pp. 335-353. doi:10.3390/microbiolres12020023

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Official URL: http://dx.doi.org/10.3390/microbiolres12020023

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Abstract

Bile acid diarrhoea (BAD) is a widespread gastrointestinal disease that is often misdiagnosed as irritable bowel syndrome and is estimated to affect 1% of the United Kingdom (UK) population alone. BAD is associated with excessive bile acid synthesis secondary to a gastrointestinal or idiopathic disorder (also known as primary BAD). Current licensed treatment in the UK has undesirable effects and has been the same since BAD was first discovered in the 1960s. Bacteria are essential in transforming primary bile acids into secondary bile acids. The profile of an individual’s bile acid pool is central in bile acid homeostasis as bile acids regulate their own synthesis. Therefore, microbiome dysbiosis incurred through changes in diet, stress levels and the introduction of antibiotics may contribute to or be the cause of primary BAD. This literature review focuses on primary BAD, providing an overview of bile acid metabolism, the role of the human gut microbiome in BAD and the potential options for therapeutic intervention in primary BAD through manipulation of the microbiome.

Item Type: Journal Article
Subjects: Q Science > QP Physiology
Q Science > QR Microbiology
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences
Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Bile acids, Diarrhea, Malabsorption syndromes -- Treatment, Microorganisms -- Therapeutic use, Medical microbiology -- Research, Bacterial genomes -- Research, Microorganisms
Journal or Publication Title: Microbiology Research
Publisher: MDPI
ISSN: 2036-7481
Official Date: 9 April 2021
Dates:
DateEvent
9 April 2021Published
3 April 2021Accepted
Volume: 12
Number: 2
Page Range: pp. 335-353
DOI: 10.3390/microbiolres12020023
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
UNSPECIFIED[NIHR] National Institute for Health Researchhttp://dx.doi.org/10.13039/501100000272

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