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Manipulating the microbiome : an alternative treatment for bile acid diarrhoea
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Hillman, Evette B. M, Rijpkema, Sjoerd, Carson, Danielle, Arasaradnam, Ramesh P., Wellington, Elizabeth M. H. and Amos, Gregory C. A. (2021) Manipulating the microbiome : an alternative treatment for bile acid diarrhoea. Microbiology Research, 12 (2). pp. 335-353. doi:10.3390/microbiolres12020023
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WRAP-manipulating-microbiome-alternative-treatment-bile-acid-diarrhoea-2021.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1304Kb) | Preview |
Official URL: http://dx.doi.org/10.3390/microbiolres12020023
Abstract
Bile acid diarrhoea (BAD) is a widespread gastrointestinal disease that is often misdiagnosed as irritable bowel syndrome and is estimated to affect 1% of the United Kingdom (UK) population alone. BAD is associated with excessive bile acid synthesis secondary to a gastrointestinal or idiopathic disorder (also known as primary BAD). Current licensed treatment in the UK has undesirable effects and has been the same since BAD was first discovered in the 1960s. Bacteria are essential in transforming primary bile acids into secondary bile acids. The profile of an individual’s bile acid pool is central in bile acid homeostasis as bile acids regulate their own synthesis. Therefore, microbiome dysbiosis incurred through changes in diet, stress levels and the introduction of antibiotics may contribute to or be the cause of primary BAD. This literature review focuses on primary BAD, providing an overview of bile acid metabolism, the role of the human gut microbiome in BAD and the potential options for therapeutic intervention in primary BAD through manipulation of the microbiome.
| Item Type: | Journal Article | ||||||
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| Subjects: | Q Science > QP Physiology Q Science > QR Microbiology |
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| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science > Life Sciences (2010- ) Faculty of Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Bile acids, Diarrhea, Malabsorption syndromes -- Treatment, Microorganisms -- Therapeutic use, Medical microbiology -- Research, Bacterial genomes -- Research, Microorganisms | ||||||
| Journal or Publication Title: | Microbiology Research | ||||||
| Publisher: | MDPI | ||||||
| ISSN: | 2036-7481 | ||||||
| Official Date: | 9 April 2021 | ||||||
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| Volume: | 12 | ||||||
| Number: | 2 | ||||||
| Page Range: | pp. 335-353 | ||||||
| DOI: | 10.3390/microbiolres12020023 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access | ||||||
| RIOXX Funder/Project Grant: |
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