Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Dysregulation of energy homeostasis in amyotrophic lateral sclerosis

Tools
- Tools
+ Tools

Guillot, Simon J., Bolborea, Matei and Dupuis, Luc (2021) Dysregulation of energy homeostasis in amyotrophic lateral sclerosis. Current Opinion in Neurology, 34 (5). pp. 773-780. doi:10.1097/WCO.0000000000000982

Research output not available from this repository, contact author.
Official URL: https://doi.org/10.1097/WCO.0000000000000982

Request Changes to record.

Abstract

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease targeting upper and lower motor neurons, inexorably leading to an early death. Defects in energy metabolism have been associated with ALS, including weight loss, increased energy expenditure, decreased body fat mass and increased use of lipid nutrients at the expense of carbohydrates. We review here recent findings on impaired energy metabolism in ALS, and its clinical importance. Hypothalamic atrophy, as well as alterations in hypothalamic peptides controlling energy metabolism, have been associated with metabolic derangements. Recent studies showed that mutations causing familial ALS impact various metabolic pathways, in particular mitochondrial function, and lipid and carbohydrate metabolism, which could underlie these metabolic defects in patients. Importantly, slowing weight loss, through high caloric diets, is a promising therapeutic strategy, and early clinical trials indicated that it might improve survival in at least a subset of patients. More research is needed to improve these therapeutic strategies, define pharmacological options, and refine the population of ALS patients that would benefit from these approaches. Dysfunctional energy homeostasis is a major feature of ALS clinical picture and emerges as a potential therapeutic target. [Abstract copyright: Copyright © 2021 Wolters Kluwer Health, Inc. All rights resereved.]

Item Type: Journal Article
Divisions: Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
SWORD Depositor: Library Publications Router
Journal or Publication Title: Current Opinion in Neurology
Publisher: Lippincott Williams & Wilkins
ISSN: 1350-7540
Official Date: October 2021
Dates:
DateEvent
October 2021Published
2 August 2021Available
Volume: 34
Number: 5
Page Range: pp. 773-780
DOI: 10.1097/WCO.0000000000000982
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Copyright Holders: Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item
twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us