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Non-invasive detection and staging of colorectal cancer using a portable electronic nose
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Tyagi, Heena, Daulton, Emma, Bannaga, Ayman S., Arasaradnam, Ramesh P. and Covington, James A. (2021) Non-invasive detection and staging of colorectal cancer using a portable electronic nose. Sensors, 21 (16). 5440. doi:10.3390/s21165440 ISSN 1424-8220.
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WRAP-non-invasive-detection-staging-colorectal-cancer-using-portable-electronic-nose-2021.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (2785Kb) | Preview |
Official URL: http://dx.doi.org/10.3390/s21165440
Abstract
Electronic noses (e-nose) offer potential for the detection of cancer in its early stages. The ability to analyse samples in real time, at a low cost, applying easy–to-use and portable equipment, gives e-noses advantages over other technologies, such as Gas Chromatography-Mass Spectrometry (GC-MS). For diseases such as cancer with a high mortality, a technology that can provide fast results for use in routine clinical applications is important. Colorectal cancer (CRC) is among the highest occurring cancers and has high mortality rates, if diagnosed late. In our study, we investigated the use of portable electronic nose (PEN3), with further analysis using GC-TOF-MS, for the analysis of gases and volatile organic compounds (VOCs) to profile the urinary metabolome of colorectal cancer. We also compared the different cancer stages with non-cancers using the PEN3 and GC-TOF-MS. Results obtained from PEN3, and GC-TOF-MS demonstrated high accuracy for the separation of CRC and non-cancer. PEN3 separated CRC from non-cancerous group with 0.81 AUC (Area Under the Curve). We used data from GC-TOF-MS to obtain a VOC profile for CRC, which identified 23 potential biomarker VOCs for CRC. Thus, the PEN3 and GC-TOF-MS were found to successfully separate the cancer group from the non-cancer group.
| Item Type: | Journal Article | ||||||
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| Subjects: | Q Science > QP Physiology R Medicine > RC Internal medicine T Technology > TK Electrical engineering. Electronics Nuclear engineering |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Engineering > Engineering Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Colon (Anatomy) -- Cancer -- Diagnosis, Colon (Anatomy) -- Cancer -- Etiology, Colon (Anatomy) -- Examination, Detectors , Olfactometry -- Equipment and supplies | ||||||
| Journal or Publication Title: | Sensors | ||||||
| Publisher: | MDPI AG | ||||||
| ISSN: | 1424-8220 | ||||||
| Official Date: | 12 August 2021 | ||||||
| Dates: |
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| Volume: | 21 | ||||||
| Number: | 16 | ||||||
| Article Number: | 5440 | ||||||
| DOI: | 10.3390/s21165440 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||
| Date of first compliant deposit: | 18 August 2021 | ||||||
| Date of first compliant Open Access: | 18 August 2021 |
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