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Non-invasive detection and staging of colorectal cancer using a portable electronic nose

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Tyagi, Heena, Daulton, Emma, Bannaga, Ayman S., Arasaradnam, Ramesh P. and Covington, James A. (2021) Non-invasive detection and staging of colorectal cancer using a portable electronic nose. Sensors, 21 (16). 5440. doi:10.3390/s21165440

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Official URL: http://dx.doi.org/10.3390/s21165440

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Abstract

Electronic noses (e-nose) offer potential for the detection of cancer in its early stages. The ability to analyse samples in real time, at a low cost, applying easy–to-use and portable equipment, gives e-noses advantages over other technologies, such as Gas Chromatography-Mass Spectrometry (GC-MS). For diseases such as cancer with a high mortality, a technology that can provide fast results for use in routine clinical applications is important. Colorectal cancer (CRC) is among the highest occurring cancers and has high mortality rates, if diagnosed late. In our study, we investigated the use of portable electronic nose (PEN3), with further analysis using GC-TOF-MS, for the analysis of gases and volatile organic compounds (VOCs) to profile the urinary metabolome of colorectal cancer. We also compared the different cancer stages with non-cancers using the PEN3 and GC-TOF-MS. Results obtained from PEN3, and GC-TOF-MS demonstrated high accuracy for the separation of CRC and non-cancer. PEN3 separated CRC from non-cancerous group with 0.81 AUC (Area Under the Curve). We used data from GC-TOF-MS to obtain a VOC profile for CRC, which identified 23 potential biomarker VOCs for CRC. Thus, the PEN3 and GC-TOF-MS were found to successfully separate the cancer group from the non-cancer group.

Item Type: Journal Article
Subjects: Q Science > QP Physiology
R Medicine > RC Internal medicine
T Technology > TK Electrical engineering. Electronics Nuclear engineering
Divisions: Faculty of Medicine > Warwick Medical School > Biomedical Sciences
Faculty of Science > Engineering
Faculty of Medicine > Warwick Medical School > Health Sciences
Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Colon (Anatomy) -- Cancer -- Diagnosis, Colon (Anatomy) -- Cancer -- Etiology, Colon (Anatomy) -- Examination, Detectors , Olfactometry -- Equipment and supplies
Journal or Publication Title: Sensors
Publisher: MDPI AG
ISSN: 1424-8220
Official Date: 12 August 2021
Dates:
DateEvent
12 August 2021Published
30 July 2021Accepted
Volume: 21
Number: 16
Article Number: 5440
DOI: 10.3390/s21165440
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access

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