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Engineering and standardization of posttranscriptional biocircuitry in Saccharomyces cerevisiae

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McCarthy, John E. G. (2021) Engineering and standardization of posttranscriptional biocircuitry in Saccharomyces cerevisiae. Integrative Biology, 13 (8). pp. 210-220. doi:10.1093/intbio/zyab013

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Official URL: https://doi.org/10.1093/intbio/zyab013

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Abstract

This short review considers to what extent posttranscriptional steps of gene expression can provide the basis for novel control mechanisms and procedures in synthetic biology and biotechnology. The term biocircuitry is used here to refer to functionally connected components comprising DNA, RNA or proteins. The review begins with an overview of the diversity of devices being developed and then considers the challenges presented by trying to engineer more scaled-up systems. While the engineering of RNA-based and protein-based circuitry poses new challenges, the resulting ‘toolsets’ of components and novel mechanisms of operation will open up multiple new opportunities for synthetic biology. However, agreed procedures for standardization will need to be placed at the heart of this expanding field if the full potential benefits are to be realized.

Item Type: Journal Article
Subjects: Q Science > QH Natural history > QH426 Genetics
T Technology > TA Engineering (General). Civil engineering (General)
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
SWORD Depositor: Library Publications Router
Library of Congress Subject Headings (LCSH): Gene expression, Synthetic biology, Saccharomyces cerevisiae -- Genetic aspects, RNA -- Structure, Ligands, Bioengineering, Biotechnology
Journal or Publication Title: Integrative Biology
Publisher: Royal Society of Chemistry
ISSN: 1757-9694
Official Date: August 2021
Dates:
DateEvent
August 2021Published
16 July 2021Available
25 June 2021Accepted
Volume: 13
Number: 8
Page Range: pp. 210-220
DOI: 10.1093/intbio/zyab013
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
H2020-NMBP-TR-IND-2018-2020/BIOTEC-01-2018[ERC] Horizon 2020 Framework Programmehttp://dx.doi.org/10.13039/100010661
BB/M017982/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268

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