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Engineering and standardization of posttranscriptional biocircuitry in Saccharomyces cerevisiae
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McCarthy, John E. G. (2021) Engineering and standardization of posttranscriptional biocircuitry in Saccharomyces cerevisiae. Integrative Biology, 13 (8). pp. 210-220. doi:10.1093/intbio/zyab013
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Official URL: https://doi.org/10.1093/intbio/zyab013
Abstract
This short review considers to what extent posttranscriptional steps of gene expression can provide the basis for novel control mechanisms and procedures in synthetic biology and biotechnology. The term biocircuitry is used here to refer to functionally connected components comprising DNA, RNA or proteins. The review begins with an overview of the diversity of devices being developed and then considers the challenges presented by trying to engineer more scaled-up systems. While the engineering of RNA-based and protein-based circuitry poses new challenges, the resulting ‘toolsets’ of components and novel mechanisms of operation will open up multiple new opportunities for synthetic biology. However, agreed procedures for standardization will need to be placed at the heart of this expanding field if the full potential benefits are to be realized.
| Item Type: | Journal Article | |||||||||
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| Subjects: | Q Science > QH Natural history > QH426 Genetics T Technology > TA Engineering (General). Civil engineering (General) |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| SWORD Depositor: | Library Publications Router | |||||||||
| Library of Congress Subject Headings (LCSH): | Gene expression, Synthetic biology, Saccharomyces cerevisiae -- Genetic aspects, RNA -- Structure, Ligands, Bioengineering, Biotechnology | |||||||||
| Journal or Publication Title: | Integrative Biology | |||||||||
| Publisher: | Royal Society of Chemistry | |||||||||
| ISSN: | 1757-9694 | |||||||||
| Official Date: | August 2021 | |||||||||
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| Volume: | 13 | |||||||||
| Number: | 8 | |||||||||
| Page Range: | pp. 210-220 | |||||||||
| DOI: | 10.1093/intbio/zyab013 | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | Published | |||||||||
| Access rights to Published version: | Open Access | |||||||||
| RIOXX Funder/Project Grant: |
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