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Defining clinically pathogenic HLA-specific antibodies - granular details in characteristics in pre and early time following HLA-antibody incompatible kidney transplantation
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Daga, Sunil, Babu, Adarsh, Khovanova, Natasha and Higgins, Rob (2021) Defining clinically pathogenic HLA-specific antibodies - granular details in characteristics in pre and early time following HLA-antibody incompatible kidney transplantation. OBM Transplantation, 5 (3). 20. doi:10.21926/obm.transplant.2103151
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WRAP-defining-clinically-pathogenic-HLA-specific-antibodies-Khovanova-2021.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (990Kb) | Preview |
Official URL: http://dx.doi.org/10.21926/obm.transplant.2103151
Abstract
Antibodies against donor HLA determine access to solid organ transplantation and in many cases the outcome of transplantation, but graft failure is not an inevitable consequence of their presence. Much research has been performed with two main aims – which antibodies represent the highest risk factor prior to transplantation, and second to understand how donor specific HLA antibodies behave after transplantation, with a long-term aim of being able to manipulate their production. HLA antibody incompatible kidney transplantation is the best model for examining antibody responses and this review looks at methods for interrogating the antibodies using ‘traditional’ snapshot techniques such as cytoxicity testing, and newer dissection techniques such as antibody subclass, complement binding and activity and affinity. Integral to the understanding of the large datasets generated is sophisticated mathematical analysis using techniques such as decision tree analysis and unsupervised machine learning. This review examines key aspects of this work, performed by us and others.
| Item Type: | Journal Article | ||||||
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| Subjects: | Q Science > QP Physiology Q Science > QR Microbiology R Medicine > RC Internal medicine R Medicine > RD Surgery |
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| Divisions: | Faculty of Science > Engineering Faculty of Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | HLA histocompatibility antigens, Kidneys -- Transplantation, Kidneys -- Transplantation -- Complications, Antibody-dependent cell cytotoxicity, Antibody-dependent cell cytotoxicity -- Mathematical models | ||||||
| Journal or Publication Title: | OBM Transplantation | ||||||
| Publisher: | LIDSEN Publishing Inc. | ||||||
| ISSN: | 25775820 | ||||||
| Official Date: | 17 August 2021 | ||||||
| Dates: |
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| Volume: | 5 | ||||||
| Number: | 3 | ||||||
| Article Number: | 20 | ||||||
| DOI: | 10.21926/obm.transplant.2103151 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access |
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