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Defining clinically pathogenic HLA-specific antibodies - granular details in characteristics in pre and early time following HLA-antibody incompatible kidney transplantation

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Daga, Sunil, Babu, Adarsh, Khovanova, Natasha and Higgins, Rob (2021) Defining clinically pathogenic HLA-specific antibodies - granular details in characteristics in pre and early time following HLA-antibody incompatible kidney transplantation. OBM Transplantation, 5 (3). 20. doi:10.21926/obm.transplant.2103151 ISSN 25775820.

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Official URL: http://dx.doi.org/10.21926/obm.transplant.2103151

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Abstract

Antibodies against donor HLA determine access to solid organ transplantation and in many cases the outcome of transplantation, but graft failure is not an inevitable consequence of their presence. Much research has been performed with two main aims – which antibodies represent the highest risk factor prior to transplantation, and second to understand how donor specific HLA antibodies behave after transplantation, with a long-term aim of being able to manipulate their production. HLA antibody incompatible kidney transplantation is the best model for examining antibody responses and this review looks at methods for interrogating the antibodies using ‘traditional’ snapshot techniques such as cytoxicity testing, and newer dissection techniques such as antibody subclass, complement binding and activity and affinity. Integral to the understanding of the large datasets generated is sophisticated mathematical analysis using techniques such as decision tree analysis and unsupervised machine learning. This review examines key aspects of this work, performed by us and others.

Item Type: Journal Article
Subjects: Q Science > QP Physiology
Q Science > QR Microbiology
R Medicine > RC Internal medicine
R Medicine > RD Surgery
Divisions: Faculty of Science, Engineering and Medicine > Engineering > Engineering
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): HLA histocompatibility antigens, Kidneys -- Transplantation, Kidneys -- Transplantation -- Complications, Antibody-dependent cell cytotoxicity, Antibody-dependent cell cytotoxicity -- Mathematical models
Journal or Publication Title: OBM Transplantation
Publisher: LIDSEN Publishing Inc.
ISSN: 25775820
Official Date: 17 August 2021
Dates:
DateEvent
17 August 2021Published
30 July 2021Accepted
Volume: 5
Number: 3
Article Number: 20
DOI: 10.21926/obm.transplant.2103151
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 25 August 2021
Date of first compliant Open Access: 25 August 2021

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