Measles antibody levels in a vaccinated population in Brazil
UNSPECIFIED. (1998) Measles antibody levels in a vaccinated population in Brazil. TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 92 (2). pp. 227-230. ISSN 0035-9203Full text not available from this repository.
An epidemiological study of measles-specific immunoglobulin G antibody levels was conducted using a representative sample of a vaccinated suburban population in Sao Paulo State, Brazil. The study aimed to determine immunity status in relation to age and infection or vaccination experience. 549 age-structured samples of sera, collected in 1990, were screened and calibrated to the international reference serum, using measles nucleoprotein in an enzyme immunoassay. In the age group with direct experience of vaccination (9 months to 15 years), whether routine or campaign, over 90% had detectable antibody greater than or equal to 50 miu/mL. However, 14% of these had antibody concentrations between 50 and 100 miu/mL and 30% between 50 and 255 miu/mL. In those over 15 years of age, 94% had antibody levels >255 miu/mL, assumed to be the result of past infection. The study suggested that, within highly vaccinated populations, a proportion of individuals had measles antibody levels which may be insufficient to protect against reinfection or clinical disease. The implications of these results, and similar findings elsewhere, in relation to the persistence of measles requires investigation; this has particular relevance in Sao Paulo following the recent measles outbreak.
|Item Type:||Journal Article|
|Subjects:||R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RC Internal medicine
|Journal or Publication Title:||TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE|
|Publisher:||ROYAL SOC TROPICAL MEDICINE|
|Number of Pages:||4|
|Page Range:||pp. 227-230|
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