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Microbial hosts for metabolic engineering of lignin bioconversion to renewable chemicals

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Bugg, Tim, Williamson, James J. and Alberti, Fabrizio (2021) Microbial hosts for metabolic engineering of lignin bioconversion to renewable chemicals. Renewable and Sustainable Energy Reviews , 152 . 111674. doi:10.1016/j.rser.2021.111674

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Official URL: https://doi.org/10.1016/j.rser.2021.111674

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Abstract

This review discusses the use of engineered microbes for bioconversion of lignin from plant biomass to produce renewable chemicals. Existing bacterial hosts for lignin bioconversion are discussed, such as Pseudomonas putida KT2440 and Rhodococcus jostii RHA1, and case studies where they have been engineered to generate aromatic and non-aromatic products are described, and the different types of lignin substrates used for these studies. Other bacteria identified as lignin degraders are described, and the prospects for using other bacteria as hosts for metabolic engineering of lignin degradation are discussed. Recent advances in genetic modification of fungi are also discussed, which could lead to the metabolic engineering of lignin-degrading fungi for bioproduct formation from lignin. Prospects and challenges in this field are discussed, as the field moves from the laboratory to industrial application, including: choice of chassis organism, choice of lignin feedstock, the complexity of polymeric lignin breakdown, and considerations for scale-up and choice of bioproduct.

Item Type: Journal Article
Alternative Title:
Subjects: Q Science > QK Botany
Divisions: Faculty of Science > Chemistry
Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Lignin, Lignin -- Biodegradation, Microbial biotechnology, Biochemical engineering, Biomass energy
Journal or Publication Title: Renewable and Sustainable Energy Reviews
Publisher: Pergamon
ISSN: 1364-0321
Official Date: December 2021
Dates:
DateEvent
December 2021Published
6 October 2021Available
7 September 2021Accepted
Volume: 152
Article Number: 111674
DOI: 10.1016/j.rser.2021.111674
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
BB/P01738X/[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
BB/T010622/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
TS/M008282/1[EPSRC] Engineering and Physical Sciences Research Councilhttp://dx.doi.org/10.13039/501100000266
ECF-2018-691Leverhulme Trusthttp://dx.doi.org/10.13039/501100000275

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