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Clathrin : the molecular shape shifter

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Wood, Katherine M. and Smith, Corinne J. (2021) Clathrin : the molecular shape shifter. Biochemical Journal, 478 (16). pp. 3099-3123. doi:10.1042/BCJ20200740

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WRAP-Clathrin-molecular-shape-shifter-Smith-2021 .pdf - Accepted Version
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Official URL: http://dx.doi.org/10.1042/BCJ20200740

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Abstract

Clathrin is best known for its contribution to clathrin-mediated endocytosis yet it also participates to a diverse range of cellular functions. Key to this is clathrin's ability to assemble into polyhedral lattices that include curved football or basket shapes, flat lattices or even tubular structures. In this review, we discuss clathrin structure and coated vesicle formation, how clathrin is utilised within different cellular processes including synaptic vesicle recycling, hormone desensitisation, spermiogenesis, cell migration and mitosis, and how clathrin's remarkable ‘shapeshifting’ ability to form diverse lattice structures might contribute to its multiple cellular functions.

Item Type: Journal Article
Subjects: Q Science > QH Natural history > QH426 Genetics
Divisions: Faculty of Science > Life Sciences (2010- )
Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Cell membranes, Chemical bonds, Molecular structure
Journal or Publication Title: Biochemical Journal
Publisher: Portland Press
ISSN: 0264-6021
Official Date: 26 August 2021
Dates:
DateEvent
26 August 2021Published
4 August 2021Accepted
Volume: 478
Number: 16
Page Range: pp. 3099-3123
DOI: 10.1042/BCJ20200740
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
MR/N014294/1[MRC] Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
BB/N008391/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
UNSPECIFIEDRoyal Societyhttp://dx.doi.org/10.13039/501100000288
UNSPECIFIEDLeverhulme Trusthttp://dx.doi.org/10.13039/501100000275

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