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Clathrin : the molecular shape shifter
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Wood, Katherine M. and Smith, Corinne J. (2021) Clathrin : the molecular shape shifter. Biochemical Journal, 478 (16). pp. 3099-3123. doi:10.1042/BCJ20200740
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WRAP-Clathrin-molecular-shape-shifter-Smith-2021 .pdf - Accepted Version Embargoed item. Restricted access to Repository staff only until 26 August 2022. Contact author directly, specifying your specific needs. - Requires a PDF viewer. Download (3272Kb) |
Official URL: http://dx.doi.org/10.1042/BCJ20200740
Abstract
Clathrin is best known for its contribution to clathrin-mediated endocytosis yet it also participates to a diverse range of cellular functions. Key to this is clathrin's ability to assemble into polyhedral lattices that include curved football or basket shapes, flat lattices or even tubular structures. In this review, we discuss clathrin structure and coated vesicle formation, how clathrin is utilised within different cellular processes including synaptic vesicle recycling, hormone desensitisation, spermiogenesis, cell migration and mitosis, and how clathrin's remarkable ‘shapeshifting’ ability to form diverse lattice structures might contribute to its multiple cellular functions.
| Item Type: | Journal Article | |||||||||||||||
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| Subjects: | Q Science > QH Natural history > QH426 Genetics | |||||||||||||||
| Divisions: | Faculty of Science > Life Sciences (2010- ) Faculty of Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Cell membranes, Chemical bonds, Molecular structure | |||||||||||||||
| Journal or Publication Title: | Biochemical Journal | |||||||||||||||
| Publisher: | Portland Press | |||||||||||||||
| ISSN: | 0264-6021 | |||||||||||||||
| Official Date: | 26 August 2021 | |||||||||||||||
| Dates: |
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| Volume: | 478 | |||||||||||||||
| Number: | 16 | |||||||||||||||
| Page Range: | pp. 3099-3123 | |||||||||||||||
| DOI: | 10.1042/BCJ20200740 | |||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||
| Publication Status: | Published | |||||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | |||||||||||||||
| RIOXX Funder/Project Grant: |
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