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Clathrin : the molecular shape shifter
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Wood, Katherine M. and Smith, Corinne J. (2021) Clathrin : the molecular shape shifter. Biochemical Journal, 478 (16). pp. 3099-3123. doi:10.1042/BCJ20200740 ISSN 0264-6021.
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Official URL: http://dx.doi.org/10.1042/BCJ20200740
Abstract
Clathrin is best known for its contribution to clathrin-mediated endocytosis yet it also participates to a diverse range of cellular functions. Key to this is clathrin's ability to assemble into polyhedral lattices that include curved football or basket shapes, flat lattices or even tubular structures. In this review, we discuss clathrin structure and coated vesicle formation, how clathrin is utilised within different cellular processes including synaptic vesicle recycling, hormone desensitisation, spermiogenesis, cell migration and mitosis, and how clathrin's remarkable ‘shapeshifting’ ability to form diverse lattice structures might contribute to its multiple cellular functions.
Item Type: | Journal Article | |||||||||||||||
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Subjects: | Q Science > QH Natural history > QH426 Genetics | |||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Cell membranes, Chemical bonds, Molecular structure | |||||||||||||||
Journal or Publication Title: | Biochemical Journal | |||||||||||||||
Publisher: | Portland Press | |||||||||||||||
ISSN: | 0264-6021 | |||||||||||||||
Official Date: | 26 August 2021 | |||||||||||||||
Dates: |
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Volume: | 478 | |||||||||||||||
Number: | 16 | |||||||||||||||
Page Range: | pp. 3099-3123 | |||||||||||||||
DOI: | 10.1042/BCJ20200740 | |||||||||||||||
Status: | Peer Reviewed | |||||||||||||||
Publication Status: | Published | |||||||||||||||
Access rights to Published version: | Restricted or Subscription Access | |||||||||||||||
Date of first compliant deposit: | 20 September 2021 | |||||||||||||||
Date of first compliant Open Access: | 26 August 2022 | |||||||||||||||
RIOXX Funder/Project Grant: |
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