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Ancient role of sulfakinin/cholecystokinin-type signalling in inhibitory regulation of feeding processes revealed in an echinoderm
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Tinoco, Ana B., Barreiro-Iglesias, Antón, Yañez Guerra, Luis Alfonso, Delroisse, Jérôme, Zhang, Ya, Gunner, Elizabeth F., Zampronio, Cleidiane G., Jones, Alexandra M., Egertová, Michaela and Elphick, Maurice R. (2021) Ancient role of sulfakinin/cholecystokinin-type signalling in inhibitory regulation of feeding processes revealed in an echinoderm. eLife, 10 . e65667. doi:10.7554/eLife.65667 ISSN 2050-084X.
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Official URL: http://dx.doi.org/10.7554/eLife.65667
Abstract
Sulfakinin (SK)/cholecystokinin (CCK)-type neuropeptides regulate feeding and digestion in protostomes (e.g. insects) and chordates. Here, we characterised SK/CCK-type signalling for the first time in a non-chordate deuterostome – the starfish Asterias rubens (phylum Echinodermata). In this species, two neuropeptides (ArSK/CCK1, ArSK/CCK2) derived from the precursor protein ArSK/CCKP act as ligands for an SK/CCK-type receptor (ArSK/CCKR) and these peptides/proteins are expressed in the nervous system, digestive system, tube feet, and body wall. Furthermore, ArSK/CCK1 and ArSK/CCK2 cause dose-dependent contraction of cardiac stomach, tube foot, and apical muscle preparations in vitro, and injection of these neuropeptides in vivo triggers cardiac stomach retraction and inhibition of the onset of feeding in A. rubens. Thus, an evolutionarily ancient role of SK/CCK-type neuropeptides as inhibitory regulators of feeding-related processes in the Bilateria has been conserved in the unusual and unique context of the extra-oral feeding behaviour and pentaradial body plan of an echinoderm.
Item Type: | Journal Article | ||||||||||||||||||||||||
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Subjects: | Q Science > QL Zoology Q Science > QP Physiology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Neuropeptides , Neuropeptides -- Receptors, Neuropeptides -- Mechanism of action, Echinodermata | ||||||||||||||||||||||||
Journal or Publication Title: | eLife | ||||||||||||||||||||||||
Publisher: | eLife Sciences Publications Ltd. | ||||||||||||||||||||||||
ISSN: | 2050-084X | ||||||||||||||||||||||||
Official Date: | 7 September 2021 | ||||||||||||||||||||||||
Dates: |
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Volume: | 10 | ||||||||||||||||||||||||
Article Number: | e65667 | ||||||||||||||||||||||||
DOI: | 10.7554/eLife.65667 | ||||||||||||||||||||||||
Status: | Peer Reviewed | ||||||||||||||||||||||||
Publication Status: | Published | ||||||||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||||||||||||||
Date of first compliant deposit: | 16 September 2021 | ||||||||||||||||||||||||
Date of first compliant Open Access: | 20 September 2021 | ||||||||||||||||||||||||
RIOXX Funder/Project Grant: |
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