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Artificial metalloenzymes as catalysts for oxidative lignin degradation
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Doble, Megan V., Jarvis, Amanda G., Ward, Andrew C. C., Colburn, Jonathan D., Götze, Jan P., Bühl, Michael and Kamer, Paul C. J. (2018) Artificial metalloenzymes as catalysts for oxidative lignin degradation. ACS Sustainable Chemistry & Engineering, 6 (11). pp. 15100-15107. doi:10.1021/acssuschemeng.8b03568 ISSN 2168-0485.
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Official URL: http://dx.doi.org/10.1021/acssuschemeng.8b03568
Abstract
We report novel artificial metalloenzymes (ArMs), containing tris(pyridylmethyl)amine (TPA), for the atom economic oxidation of lignin β-O-4 model compounds, using hydrogen peroxide. The protein scaffold alters the selectivity of the reaction from a low yielding cleavage reaction when using the parent Fe-tpa complex to a high yielding benzylic alcohol oxidation when using the complex incorporated into a protein scaffold, SCP-2L A100C. Engineering the protein scaffold to incorporate glutamic acid was found to improve the ArM activity, showing that rational design of the protein environment using metal binding amino acids can be a first step toward improving the overall activity of an artificial metalloenzyme.
Item Type: | Journal Article | ||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||
Journal or Publication Title: | ACS Sustainable Chemistry & Engineering | ||||||
Publisher: | American Chemical Society | ||||||
ISSN: | 2168-0485 | ||||||
Official Date: | 5 November 2018 | ||||||
Dates: |
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Volume: | 6 | ||||||
Number: | 11 | ||||||
Page Range: | pp. 15100-15107 | ||||||
DOI: | 10.1021/acssuschemeng.8b03568 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||
Copyright Holders: | American Chemical Society |
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