The Library
Life cycle assessment of an enzymatic ibuprofen production process with automatic recycling and purification
Tools
Grimaldi, Fabio, Tran, Nam Nghiep, Sarafraz, M. M., Lettieri, Paola, Morales-Gonzalez, Olivia Maria and Hessel, Volker (2021) Life cycle assessment of an enzymatic ibuprofen production process with automatic recycling and purification. ACS Sustainable Chemistry & Engineering, 9 (39). pp. 13135-13150. doi:10.1021/acssuschemeng.1c02309 ISSN 2168-0485.
|
PDF
WRAP-Life-cycle-assessment-enzymatic-ibuprofen-automatic-recycling-purification-2021.pdf - Accepted Version - Requires a PDF viewer. Download (1620Kb) | Preview |
Official URL: https://doi.org/10.1021/acssuschemeng.1c02309
Abstract
In this study, the environmental impacts of three ibuprofen production routes, namely, the BHC, the Bogdan, and the newly developed enzymatic synthetic routes (modified Bogdan process), are assessed and compared by the application of life cycle assessment (LCA). Based on the data obtained through literature and laboratory-based experiments, a pilot-scale production with a capacity of 500 g/day of ibuprofen was simulated to generate inventory data for the LCA study, using Aspen Plus V11. The well-established BHC process was chosen as the benchmark to quantify the operational and environmental benefits of the innovative enzymatic Bogdan flow synthetic process. The comparison highlights the benefit of adopting the modified Bogdan synthesis route via an enzymatic catalyst. Results show that a general reduction of environmental impact is achievable across the whole set of impact categories of the analysis, and the magnitude of such reduction depends on the efficiency of recycling in the production system. Considering a 50% efficiency of recycling, the modified Bogdan system achieves lower environmental impacts in some impact categories like Acidification, Ecotoxicity of freshwater, Human toxicity, Particulate matter, and Resource depletion (mineral, fossils, renewables) while having higher impacts on the rest of the impact categories. Yet, the new process proposed here scores better environmental performances in all of the impact categories when the enzyme recycling is close to 100%, which is promising for future technology development.
Item Type: | Journal Article | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Subjects: | H Social Sciences > HF Commerce Q Science > QC Physics R Medicine > RM Therapeutics. Pharmacology T Technology > TP Chemical technology |
|||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | |||||||||
SWORD Depositor: | Library Publications Router | |||||||||
Library of Congress Subject Headings (LCSH): | Ibuprofen , Product life cycle, Chemical processes, Chemical process control -- Simulation methods, Anions, Enzymes -- Biotechnology | |||||||||
Journal or Publication Title: | ACS Sustainable Chemistry & Engineering | |||||||||
Publisher: | American Chemical Society (ACS) | |||||||||
ISSN: | 2168-0485 | |||||||||
Official Date: | 4 October 2021 | |||||||||
Dates: |
|
|||||||||
Volume: | 9 | |||||||||
Number: | 39 | |||||||||
Page Range: | pp. 13135-13150 | |||||||||
DOI: | 10.1021/acssuschemeng.1c02309 | |||||||||
Status: | Peer Reviewed | |||||||||
Publication Status: | Published | |||||||||
Reuse Statement (publisher, data, author rights): | ** From Crossref journal articles via Jisc Publications Router ** History: epub 17-09-2021; issued 17-09-2021. | |||||||||
Access rights to Published version: | Restricted or Subscription Access | |||||||||
Copyright Holders: | Copyright © 2021 American Chemical Society | |||||||||
Date of first compliant deposit: | 1 November 2021 | |||||||||
Date of first compliant Open Access: | 17 September 2022 | |||||||||
RIOXX Funder/Project Grant: |
|
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |
Downloads
Downloads per month over past year