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An improved assembly of the Albugo candida Ac2V genome reveals the expansion of the “CCG” class of effectors

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Furzer, Oliver, Cevik, Volkan, Fairhead, Sebastian, Bailey, Kate, Redkar, Amey, Schudmoma, Christian, MacLean, Dan, Holub, E. B. and Jones, Jonathan D. G. (2022) An improved assembly of the Albugo candida Ac2V genome reveals the expansion of the “CCG” class of effectors. Molecular Plant-Microbe Interactions, 35 (1). pp. 39-48. doi:10.1094/mpmi-04-21-0075-r

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Official URL: https://doi.org/10.1094/MPMI-04-21-0075-R

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Abstract

Albugo candida is an obligate oomycete pathogen that infects many plants in the Brassicaceae family. We re-sequenced the genome of isolate Ac2V using PacBio long reads and constructed an assembly augmented by Illumina reads. The Ac2VPB genome assembly is 10% larger and more contiguous compared to a previous version. Our annotation of the new assembly, aided by RNASeq information, revealed a 175% expansion (40 to 110) in the CHxC effector class, which we redefined as “CCG” based on motif analysis. This class of effectors consist of arrays of phylogenetically related paralogs residing in gene sparse regions, and shows signatures of positive selection and presence/absence polymorphism. This work provides a resource that allows the dissection of the genomic components underlying A. candida adaptation and particularly the role of CCG effectors in virulence and avirulence on different hosts.

Item Type: Journal Article
Subjects: Q Science > QK Botany
S Agriculture > SB Plant culture
Divisions: Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
SWORD Depositor: Library Publications Router
Library of Congress Subject Headings (LCSH): Albugo candida -- Genetics, Cruciferae -- Diseases and pests
Journal or Publication Title: Molecular Plant-Microbe Interactions
Publisher: The American Phytopathological Society
ISSN: 0894-0282
Official Date: January 2022
Dates:
DateEvent
January 2022Published
21 September 2021Available
7 June 2021Accepted
Volume: 35
Number: 1
Page Range: pp. 39-48
DOI: 10.1094/mpmi-04-21-0075-r
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
BB/L011646/1Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
BB/M003809/1Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
ALTF-842-2015European Molecular Biology Organizationhttp://dx.doi.org/10.13039/100004410
233376European Research Councilhttp://dx.doi.org/10.13039/501100000781

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