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Stable iron oxide nanoflowers with exceptional magnetic heating efficiency : simple and fast polyol synthesis
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Storozhuk, Liudmyla, Besenhard, Maximilian O,, Mourdikoudis, Stefanos, LaGrow, Alec P., Lees, Martin R., Tung, Le Duc, Gavriilidis, Asterios and Thanh, Nguyen Thi Kim (2021) Stable iron oxide nanoflowers with exceptional magnetic heating efficiency : simple and fast polyol synthesis. ACS Applied Materials & Interfaces, 13 (38). pp. 45870-45880. doi:10.1021/acsami.1c12323 ISSN 1944-8244.
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WRAP-Stable-iron-oxide-nanoflowers-exceptional-magnetic-heating-2021.pdf - Accepted Version - Requires a PDF viewer. Download (1892Kb) | Preview |
Official URL: https://doi.org/10.1021/acsami.1c12323
Abstract
Magnetically induced hyperthermia has reached a milestone in medical nanoscience and in phase III clinical trials for cancer treatment. As it relies on the heat generated by magnetic nanoparticles (NPs) when exposed to an external alternating magnetic field, the heating ability of these NPs is of paramount importance, so is their synthesis. We present a simple and fast method to produce iron oxide nanostructures with excellent heating ability that are colloidally stable in water. A polyol process yielded biocompatible single core nanoparticles and nanoflowers. The effect of parameters such as the precursor concentration, polyol molecular weight as well as reaction time was studied, aiming to produce NPs with the highest possible heating rates. Polyacrylic acid facilitated the formation of excellent nanoheating agents iron oxide nanoflowers (IONFs) within 30 min. The progressive increase of the size of the NFs through applying a seeded growth approach resulted in outstanding enhancement of their heating efficiency with intrinsic loss parameter up to 8.49 nH m kg . The colloidal stability of the NFs was maintained when transferring to an aqueous solution via a simple ligand exchange protocol, replacing polyol ligands with biocompatible sodium tripolyphosphate to secure the IONPs long-term colloidal stabilization.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica T Technology > TA Engineering (General). Civil engineering (General) |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Physics | ||||||||
SWORD Depositor: | Library Publications Router | ||||||||
Library of Congress Subject Headings (LCSH): | Nanoparticles, Nanomedicine -- Therapeutic use, Iron oxides -- Magnetic properties, Nanostructured materials -- Research | ||||||||
Journal or Publication Title: | ACS Applied Materials & Interfaces | ||||||||
Publisher: | American Chemical Society | ||||||||
ISSN: | 1944-8244 | ||||||||
Official Date: | 29 September 2021 | ||||||||
Dates: |
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Volume: | 13 | ||||||||
Number: | 38 | ||||||||
Page Range: | pp. 45870-45880 | ||||||||
DOI: | 10.1021/acsami.1c12323 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Reuse Statement (publisher, data, author rights): | “This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Materials & Interfaces, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see http://pubs.acs.org/page/policy/articlesonrequest/index.html].” | ||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||
Date of first compliant deposit: | 26 October 2021 | ||||||||
Date of first compliant Open Access: | 20 September 2022 | ||||||||
RIOXX Funder/Project Grant: |
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