Chiral phosphinamides: new catalysts for the asymmetric reduction of ketones by borane
UNSPECIFIED. (1998) Chiral phosphinamides: new catalysts for the asymmetric reduction of ketones by borane. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 (6). pp. 1027-1038. ISSN 0300-922XFull text not available from this repository.
We have identified a new class of catalysts for the asymmetric reduction of prochiral ketones by borane. Key to the architecture of effective catalysts is an N-P=O structural unit which may be part of a phosphinamide, phosphonamide or a related structure, Such catalysts are simple to prepare, are often crystalline solids and may be recovered from reduction reactions and reused. The catalysts act essentially as Lewis bases, serving to increase the reactivity of borane by electron donation. The incorporation of a hydroxy group into the catalyst provides an adjacent Lewis acid site upon reaction with borane and thus affords a superior catalyst capable of asymmetric inductions of up to 92% ee.
|Item Type:||Journal Article|
|Subjects:||Q Science > QD Chemistry|
|Journal or Publication Title:||JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1|
|Publisher:||ROYAL SOC CHEMISTRY|
|Official Date:||21 March 1998|
|Number of Pages:||12|
|Page Range:||pp. 1027-1038|
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