The Library
The enpp4 ectonucleotidase regulates kidney patterning signalling networks in Xenopus embryos
Tools
Tools
Tools
Masse, Karine , Bhamra, Surinder, Paroissin, Christian, Maneta-Peyret, Lilly, Boué-Grabot, Eric and Jones, Elizabeth A. (2021) The enpp4 ectonucleotidase regulates kidney patterning signalling networks in Xenopus embryos. Communications Biology, 4 (1). 1158. doi:10.1038/s42003-021-02688-9
|
PDF
WRAP-enpp4-ectonucleotidase-kidney-signalling-Xenopus-embryos-2021.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (8Mb) | Preview |
Official URL: https://doi.org/10.1038/s42003-021-02688-9
Abstract
The enpp ectonucleotidases regulate lipidic and purinergic signalling pathways by controlling the extracellular concentrations of purines and bioactive lipids. Although both pathways are key regulators of kidney physiology and linked to human renal pathologies, their roles during nephrogenesis remain poorly understood. We previously showed that the pronephros was a major site of enpp expression and now demonstrate an unsuspected role for the conserved vertebrate enpp4 protein during kidney formation in Xenopus. Enpp4 over-expression results in ectopic renal tissues and, on rare occasion, complete mini-duplication of the entire kidney. Enpp4 is required and sufficient for pronephric markers expression and regulates the expression of RA, Notch and Wnt pathway members. Enpp4 is a membrane protein that binds, without hydrolyzing, phosphatidylserine and its effects are mediated by the receptor s1pr5, although not via the generation of S1P. Finally, we propose a novel and non-catalytic mechanism by which lipidic signalling regulates nephrogenesis.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QH Natural history > QH301 Biology Q Science > QP Physiology |
||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||
| SWORD Depositor: | Library Publications Router | ||||||
| Library of Congress Subject Headings (LCSH): | Kidneys -- Growth, Developmental biology, Xenopus -- Embryology | ||||||
| Journal or Publication Title: | Communications Biology | ||||||
| Publisher: | Nature Publishing Group UK | ||||||
| ISSN: | 2399-3642 | ||||||
| Official Date: | 7 October 2021 | ||||||
| Dates: |
|
||||||
| Volume: | 4 | ||||||
| Number: | 1 | ||||||
| Article Number: | 1158 | ||||||
| DOI: | 10.1038/s42003-021-02688-9 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access | ||||||
| RIOXX Funder/Project Grant: |
|
||||||
| Related URLs: |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
