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The enpp4 ectonucleotidase regulates kidney patterning signalling networks in Xenopus embryos

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Masse, Karine , Bhamra, Surinder, Paroissin, Christian, Maneta-Peyret, Lilly, Boué-Grabot, Eric and Jones, Elizabeth A. (2021) The enpp4 ectonucleotidase regulates kidney patterning signalling networks in Xenopus embryos. Communications Biology, 4 (1). 1158. doi:10.1038/s42003-021-02688-9

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Official URL: https://doi.org/10.1038/s42003-021-02688-9

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Abstract

The enpp ectonucleotidases regulate lipidic and purinergic signalling pathways by controlling the extracellular concentrations of purines and bioactive lipids. Although both pathways are key regulators of kidney physiology and linked to human renal pathologies, their roles during nephrogenesis remain poorly understood. We previously showed that the pronephros was a major site of enpp expression and now demonstrate an unsuspected role for the conserved vertebrate enpp4 protein during kidney formation in Xenopus. Enpp4 over-expression results in ectopic renal tissues and, on rare occasion, complete mini-duplication of the entire kidney. Enpp4 is required and sufficient for pronephric markers expression and regulates the expression of RA, Notch and Wnt pathway members. Enpp4 is a membrane protein that binds, without hydrolyzing, phosphatidylserine and its effects are mediated by the receptor s1pr5, although not via the generation of S1P. Finally, we propose a novel and non-catalytic mechanism by which lipidic signalling regulates nephrogenesis.

Item Type: Journal Article
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QP Physiology
Divisions: Faculty of Science > Life Sciences (2010- )
SWORD Depositor: Library Publications Router
Library of Congress Subject Headings (LCSH): Kidneys -- Growth, Developmental biology, Xenopus -- Embryology
Journal or Publication Title: Communications Biology
Publisher: Nature Publishing Group UK
ISSN: 2399-3642
Official Date: 7 October 2021
Dates:
DateEvent
7 October 2021Published
17 September 2021Accepted
Volume: 4
Number: 1
Article Number: 1158
DOI: 10.1038/s42003-021-02688-9
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
082071Wellcome Trusthttp://dx.doi.org/10.13039/100010269
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