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Endemic persistence of a highly contagious pathogen : foot-and-mouth disease in its wildlife host
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Jolles, Anna, Gorsich, Erin E., Gubbins, Simon, Beechler, Brianna, Buss, Peter, Juleff, Nick, de Klerk-Lorist, Lin-Mari, Maree, Francois, Perez-Martin, Eva, van Schalkwyk, O. L., Scott, Katherine, Zhang, Fuquan, Medlock, Jan and Charleston, Bryan (2021) Endemic persistence of a highly contagious pathogen : foot-and-mouth disease in its wildlife host. Science, 374 (6563). pp. 104-109. doi:10.1126/science.abd2475 ISSN 0036-8075.
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Official URL: https://doi.org/10.1126/science.abd2475
Abstract
Extremely contagious pathogens are a global biosecurity threat because of their high burden of morbidity and mortality, as well as their capacity for fast-moving epidemics that are difficult to quell. Understanding the mechanisms enabling persistence of highly transmissible pathogens in host populations is thus a central problem in disease ecology. Through a combination of experimental and theoretical approaches, we investigated how highly contagious foot-and-mouth disease viruses persist in the African buffalo, which serves as their wildlife reservoir. We found that viral persistence through transmission among acutely infected hosts alone is unlikely. However, the inclusion of occasional transmission from persistently infected carriers reliably rescues the most infectious viral strain from fade-out. Additional mechanisms such as antigenic shift, loss of immunity, or spillover among host populations may be required for persistence of less transmissible strains.
| Item Type: | Journal Article | ||||||||||||||||||
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| Subjects: | Q Science > QR Microbiology S Agriculture > SF Animal culture |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||||||||||||
| SWORD Depositor: | Library Publications Router | ||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Pathogenic microorganisms, Foot-and-mouth disease, African buffalo -- Viruses, Communicable diseases in animals -- Transmission | ||||||||||||||||||
| Journal or Publication Title: | Science | ||||||||||||||||||
| Publisher: | American Association for the Advancement of Science | ||||||||||||||||||
| ISSN: | 0036-8075 | ||||||||||||||||||
| Official Date: | 1 October 2021 | ||||||||||||||||||
| Dates: |
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| Volume: | 374 | ||||||||||||||||||
| Number: | 6563 | ||||||||||||||||||
| Page Range: | pp. 104-109 | ||||||||||||||||||
| DOI: | 10.1126/science.abd2475 | ||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||
| Reuse Statement (publisher, data, author rights): | “This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science on 374(6563) https://doi.org/10.1126/science.abd2475 | ||||||||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||||||||||||
| Date of first compliant deposit: | 12 October 2021 | ||||||||||||||||||
| Date of first compliant Open Access: | 1 April 2022 | ||||||||||||||||||
| RIOXX Funder/Project Grant: |
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