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Toward glycomaterials with selectivity as well as affinity
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Richards, Sarah-Jane and Gibson, Matthew I. (2021) Toward glycomaterials with selectivity as well as affinity. JACS Au, 1 (12). pp. 2089-2099. doi:10.1021/jacsau.1c00352 ISSN 2691-3704.
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WRAP-Toward-Glycomaterials-selectivity-affinity-2021.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons: Attribution-Noncommercial 4.0. Download (3534Kb) | Preview |
Official URL: http://dx.doi.org/10.1021/jacsau.1c00352
Abstract
Multivalent glycosylated materials (polymers, surfaces, and particles) often show high affinity toward carbohydrate binding proteins (e.g., lectins) due to the nonlinear enhancement from the cluster glycoside effect. This affinity gain has potential in applications from diagnostics, biosensors, and targeted delivery to anti-infectives and in an understanding of basic glycobiology. This perspective highlights the question of selectivity, which is less often addressed due to the reductionist nature of glycomaterials and the promiscuity of many lectins. The use of macromolecular features, including architecture, heterogeneous ligand display, and the installation of non-natural glycans, to address this challenge is discussed, and examples of selectivity gains are given.
Item Type: | Journal Article | ||||||||||||||||||
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Subjects: | Q Science > QD Chemistry Q Science > QP Physiology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Carbohydrates, Polymers -- Biotechnology, Carbohydrates -- Biotechnology, Multivalent molecules, Polymerization, Glycoconjugates | ||||||||||||||||||
Journal or Publication Title: | JACS Au | ||||||||||||||||||
Publisher: | American Chemical Society | ||||||||||||||||||
ISSN: | 2691-3704 | ||||||||||||||||||
Official Date: | 27 December 2021 | ||||||||||||||||||
Dates: |
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Volume: | 1 | ||||||||||||||||||
Number: | 12 | ||||||||||||||||||
Page Range: | pp. 2089-2099 | ||||||||||||||||||
DOI: | 10.1021/jacsau.1c00352 | ||||||||||||||||||
Status: | Peer Reviewed | ||||||||||||||||||
Publication Status: | Published | ||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||||||||
Copyright Holders: | © 2021 The Authors. Published by American Chemical Society | ||||||||||||||||||
Date of first compliant deposit: | 12 October 2021 | ||||||||||||||||||
Date of first compliant Open Access: | 12 October 2021 | ||||||||||||||||||
RIOXX Funder/Project Grant: |
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