Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Added value of magnetic resonance spectroscopy for diagnosing childhood cerebellar tumours

Tools
- Tools
+ Tools

Davies, Nigel P., Rose, Heather E. L., Manias, Karen A., Natarajan, Kal, Abernethy, Laurence J., Oates, Adam, Janjua, Umair, Davies, Paul, MacPherson, Lesley, Arvanitis, Theodoros N. and Peet, Andrew C. (2022) Added value of magnetic resonance spectroscopy for diagnosing childhood cerebellar tumours. NMR in Biomedicine, 35 (2). e4630. doi:10.1002/nbm.4630

[img]
Preview
PDF
WRAP-added-value-magnetic-resonance-spectroscopy-diagnosing-childhood-cerebellar-tumours-Arvanitis-2021.pdf - Published Version - Requires a PDF viewer.
Available under License Creative Commons Attribution 4.0.

Download (1664Kb) | Preview
Official URL: https://doi.org/10.1002/nbm.4630

Request Changes to record.

Abstract

1H‐magnetic resonance spectroscopy (MRS) provides noninvasive metabolite profiles with the potential to aid the diagnosis of brain tumours. Prospective studies of diagnostic accuracy and comparisons with conventional MRI are lacking. The aim of the current study was to evaluate, prospectively, the diagnostic accuracy of a previously established classifier for diagnosing the three major childhood cerebellar tumours, and to determine added value compared with standard reporting of conventional imaging. Single‐voxel MRS (1.5 T, PRESS, TE 30 ms, TR 1500 ms, spectral resolution 1 Hz/point) was acquired prospectively on 39 consecutive cerebellar tumours with histopathological diagnoses of pilocytic astrocytoma, ependymoma or medulloblastoma. Spectra were analysed with LCModel and predefined quality control criteria were applied, leaving 33 cases in the analysis. The MRS diagnostic classifier was applied to this dataset. A retrospective analysis was subsequently undertaken by three radiologists, blind to histopathological diagnosis, to determine the change in diagnostic certainty when sequentially viewing conventional imaging, MRS and a decision support tool, based on the classifier. The overall classifier accuracy, evaluated prospectively, was 91%. Incorrectly classified cases, two anaplastic ependymomas, and a rare histological variant of medulloblastoma, were not well represented in the original training set. On retrospective review of conventional MRI, MRS and the classifier result, all radiologists showed a significant increase (Wilcoxon signed rank test, p < 0.001) in their certainty of the correct diagnosis, between viewing the conventional imaging and MRS with the decision support system. It was concluded that MRS can aid the noninvasive diagnosis of posterior fossa tumours in children, and that a decision support classifier helps in MRS interpretation.

Item Type: Journal Article
Subjects: R Medicine > RJ Pediatrics
Divisions: Faculty of Science, Engineering and Medicine > Engineering > WMG (Formerly the Warwick Manufacturing Group)
SWORD Depositor: Library Publications Router
Library of Congress Subject Headings (LCSH): Cerebellum -- Diseases, Nuclear magnetic resonance spectroscopy -- Diagnostic use, Brain -- Diseases -- Diagnosis, Pediatric neurology -- Research
Journal or Publication Title: NMR in Biomedicine
Publisher: John Wiley & Sons Ltd.
ISSN: 0952-3480
Official Date: February 2022
Dates:
DateEvent
February 2022Published
13 October 2021Available
15 September 2021Accepted
Volume: 35
Number: 2
Article Number: e4630
DOI: 10.1002/nbm.4630
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
NIHR-RP-R2-12-019[NIHR] National Institute for Health Researchhttp://dx.doi.org/10.13039/501100000272
C7809/A10342[MRC] Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
C7809/A10342Department of Health and Social CareUNSPECIFIED
C8232/A25261Experimental Cancer Medicine Centre Paediatric NetworkUNSPECIFIED
BCHRF513Birmingham Children's Hospital NHS Foundation Trusthttp://viaf.org/viaf/171267609
CCLGA 2019 26Children's Cancer and Leukaemia Grouphttp://dx.doi.org/10.13039/100011692

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics

twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us