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Characterization of gold nanorods conjugated with synthetic glycopolymers using an analytical approach based on spICP-SFMS and EAF4-MALS
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Velimirovic, Milica, Pancaro, Alessia, Mildner, Robert, Georgiou, Panagiotis G., Tirez, Kristof, Nelissen, Inge, Johann, Christoph, Gibson, Matthew I. and Vanhaecke, Frank (2021) Characterization of gold nanorods conjugated with synthetic glycopolymers using an analytical approach based on spICP-SFMS and EAF4-MALS. Nanomaterials, 11 (10). 2720. doi:10.3390/nano11102720
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WRAP-Characterization-gold-nanorods-conjugated-glycopolymers-spICP-SFMS-EAF4-MALS-2021.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (648Kb) | Preview |
Official URL: https://doi.org/10.3390/nano11102720
Abstract
A new comprehensive analytical approach based on single-particle inductively coupled plasma-sector field mass spectrometry (spICP-SFMS) and electrical asymmetric-flow field-flow-fractionation combined with multi-angle light scattering detection (EAF4-MALS) has been examined for the characterization of galactosamine-terminated poly(N-hydroxyethyl acrylamide)-coated gold nanorods (GNRs) in two different degrees of polymerization (DP) by tuning the feed ratio (short: DP 35; long: DP 60). spICP-SFMS provided information on the particle number concentration, size and size distribution of the GNRs, and was found to be useful as an orthogonal method for fast characterization of GNRs. Glycoconjugated GNRs were separated and characterized via EAF4-MALS in terms of their size and charge and compared to the bare GNRs. In contrast to spICP-SFMS, EAF4-MALS was also able of providing an estimate of the thickness of the glycopolymer coating on the GNRs surface.
| Item Type: | Journal Article | |||||||||
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| Subjects: | Q Science > QC Physics Q Science > QD Chemistry Q Science > QE Geology T Technology > TA Engineering (General). Civil engineering (General) |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Nanotechnology -- Research, Nanostructured materials, Gold -- Spectra, Bioconjugates, Copolymers -- Synthesis, High resolution spectroscopy, Field-flow fractionation, Light -- Scattering | |||||||||
| Journal or Publication Title: | Nanomaterials | |||||||||
| Publisher: | MDPI Publishing | |||||||||
| ISSN: | 1847-9804 | |||||||||
| Official Date: | 15 October 2021 | |||||||||
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| Volume: | 11 | |||||||||
| Number: | 10 | |||||||||
| Article Number: | 2720 | |||||||||
| DOI: | 10.3390/nano11102720 | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | Published | |||||||||
| Access rights to Published version: | Open Access | |||||||||
| RIOXX Funder/Project Grant: |
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