Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Association between parental age, brain structure, and behavioral and cognitive problems in children

Tools
- Tools
+ Tools

Du, Jingnan, Rolls, Edmund T., Gong, Weikang, Cao, Miao, Vatansever, Deniz, Zhang, Jie, Kang, Jujiao, Cheng, Wei and Feng, Jianfeng (2021) Association between parental age, brain structure, and behavioral and cognitive problems in children. Molecular Psychiatry . doi:10.1038/s41380-021-01325-5 (In Press)

Research output not available from this repository, contact author.
Official URL: https://doi.org/10.1038/s41380-021-01325-5

Request Changes to record.

Abstract

Objective:
To investigate the relation between parental age, and behavioral, cognitive and brain differences in the children.

Method:
Data with children aged 9–11 of 8709 mothers with parental age 15–45 years were analyzed from the Adolescent Brain Cognitive Development (ABCD) study. A general linear model was used to test the associations of the parental age with brain structure, and behavioral and cognitive problems scores.

Results:
Behavioral and cognitive problems were greater in the children of the younger mothers, and were associated with lower volumes of cortical regions in the children. There was a linear correlation between the behavioral and cognitive problems scores, and the lower brain volumes (r > 0.6), which was evident when parental age was included as a stratification factor. The regions with lower volume included the anterior cingulate cortex, medial and lateral orbitofrontal cortex and amygdala, parahippocampal gyrus and hippocampus, and temporal lobe (FDR corrected p < 0.01). The lower cortical volumes and areas in the children significantly mediated the association between the parental age and the behavioral and cognitive problems in the children (all p < 10−4). The effects were large, such as the 71.4% higher depressive problems score, and 27.5% higher rule-breaking score, in the children of mothers aged 15–19 than the mothers aged 34–35.

Conclusions:
Lower parental age is associated with behavioral problems and reduced cognitive performance in the children, and these differences are related to lower volumes and areas of some cortical regions which mediate the effects in the children. The findings are relevant to psychiatric understanding and assessment.

Item Type: Journal Article
Divisions: Faculty of Science > Computer Science
SWORD Depositor: Library Publications Router
Journal or Publication Title: Molecular Psychiatry
Publisher: Nature Publishing Group
ISSN: 1359-4184
Official Date: 14 October 2021
Dates:
DateEvent
14 October 2021Published
27 September 2021Accepted
DOI: 10.1038/s41380-021-01325-5
Status: Peer Reviewed
Publication Status: In Press
Access rights to Published version: Restricted or Subscription Access

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item
twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us