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The evolutionary origins of peroxynitrite signalling
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Miles, Jennifer A., Egan, Joseph L., Fowler, Jake A., Machattou, Petrina, Millard, Andrew D., Perry, Christopher, Scanlan, David J. and Taylor, Paul C. (2021) The evolutionary origins of peroxynitrite signalling. Biochemical and Biophysical Research Communications, 580 . pp. 107-112. doi:10.1016/j.bbrc.2021.09.071 ISSN 0006-291X.
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WRAP-Evolutionary-origins-peroxynitrite-signalling-2021.pdf - Accepted Version - Requires a PDF viewer. Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. Download (818Kb) | Preview |
Official URL: https://doi.org/10.1016/j.bbrc.2021.09.071
Abstract
Peroxynitrite is a reactive intermediate formed in vivo through uncatalysed reaction of superoxide and nitric oxide radicals. Despite significant interest in detecting peroxynitrite in vivo and understanding its production, little attention has been given to the evolutionary origins of peroxynitrite signalling. Herein we focus on two enzymes that are key to the biosynthesis of superoxide and nitric oxide, NADPH oxidase 5 (NOX5) and endothelial nitric oxide synthase (eNOS), respectively. Multiple sequence alignments of both enzymes including homologues from all domains of life, coupled with a phylogenetic analysis of NOX5, suggest eNOS and NOX5 are present in animals as the result of horizontal gene transfer from ancestral cyanobacteria to ancestral eukaryotes. Therefore, biochemical studies from other laboratories on a NOX5 homologue in Cylindrospermum stagnale and an eNOS homologue in Synechococcus sp. PCC 7335 are likely to be of relevance to human NOX5 and eNOS and to the production of superoxide, nitric oxide and peroxynitrite in humans.
| Item Type: | Journal Article | |||||||||
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| Subjects: | Q Science > QD Chemistry Q Science > QP Physiology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) |
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| Library of Congress Subject Headings (LCSH): | Peroxynitrite, Peroxynitrite -- Evolution, Nitric-oxide synthase, Oxidases | |||||||||
| Journal or Publication Title: | Biochemical and Biophysical Research Communications | |||||||||
| Publisher: | Elsevier | |||||||||
| ISSN: | 0006-291X | |||||||||
| Official Date: | 26 November 2021 | |||||||||
| Dates: |
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| Volume: | 580 | |||||||||
| Page Range: | pp. 107-112 | |||||||||
| DOI: | 10.1016/j.bbrc.2021.09.071 | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | Published | |||||||||
| Access rights to Published version: | Restricted or Subscription Access | |||||||||
| Date of first compliant deposit: | 25 October 2021 | |||||||||
| Date of first compliant Open Access: | 30 September 2022 | |||||||||
| RIOXX Funder/Project Grant: |
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