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Truncating Tau reveals different pathophysiological actions of oligomers in single neurons

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Hill, Emily, Karikari, Thomas K., Lantero-Rodriguez, Juan, Zetterberg, Henrik, Blennow, Kaj, Richardson, Magnus J. E. and Wall, Mark J. (2021) Truncating Tau reveals different pathophysiological actions of oligomers in single neurons. Communications Biology, 4 . 1265 . doi:10.1038/s42003-021-02791-x

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Official URL: https://doi.org/10.1038/s42003-021-02791-x

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Abstract

Tau protein is involved in maintaining the structural integrity of neurons. In tauopathies, including Alzheimer’s disease, tau forms oligomers, which can modulate neuronal function. Previously the introduction of oligomeric full-length human tau (aa 1-441; FL-oTau) into pyramidal neurons decreased whole-cell conductance, increased excitability and changed the action potential (AP) waveform. Introducing N-terminally truncated tau (aa 124-441; CFRAG) removed the effects on the AP waveform and input resistance but the increase in excitability remained. A hyperpolarising shift in spike threshold underlies this increase in excitability. The N-terminal fragment (aa 1-123; NFRAG) markedly increased input resistance and changed the AP waveform. Lower concentrations of NFRAG only changed the AP waveform. Thus the two truncations can recapitulate the effects of FL-oTau. To investigate underlying mechanisms, we recorded sodium currents and found that FL-oTau lowers the activation voltage and reduced the maximal conductance, consistent with the lower spike threshold and reduction in AP amplitude

Item Type: Journal Article
Subjects: Q Science > QP Physiology
R Medicine > RC Internal medicine
Divisions: Faculty of Science > Life Sciences (2010- )
Faculty of Science > Mathematics
Library of Congress Subject Headings (LCSH): Alzheimer's disease -- Pathophysiology, Amyloid beta-protein, Nerve tissue proteins, Oligomers , Neurons, Nervous system -- Diseases
Journal or Publication Title: Communications Biology
Publisher: Nature Publishing Group
ISSN: 2399-3642
Official Date: 4 November 2021
Dates:
DateEvent
4 November 2021Published
14 October 2021Accepted
Volume: 4
Article Number: 1265
DOI: 10.1038/s42003-021-02791-x
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
UNSPECIFIED[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
UNSPECIFIEDAlzheimer's Associationhttp://dx.doi.org/10.13039/100000957
Barbara Naylor Charitable Trust FellowshipRace against dementiahttps://www.raceagainstdementia.com/
A2020812FBrightFocus Foundationhttp://dx.doi.org/10.13039/100006312
UNSPECIFIEDAlzheimerfondenhttp://dx.doi.org/10.13039/501100008599
UNSPECIFIEDDemensförbundethttp://dx.doi.org/10.13039/100010773
UNSPECIFIEDParkinsonfondenhttp://dx.doi.org/10.13039/100008444
UNSPECIFIEDStiftelsen för Gamla Tjänarinnorhttp://dx.doi.org/10.13039/100010815
UNSPECIFIED(Ann) Wallströms and Mary-Ann Sjöbloms FoundationUNSPECIFIED
UNSPECIFIEDGun & Bertil Stohnes FoundationUNSPECIFIED
UNSPECIFIEDAnna Lisa and Brother Björnsson’s FoundationUNSPECIFIED
2018-02532Vetenskapsrådethttp://dx.doi.org/10.13039/501100004359
681712European Research Councilhttp://dx.doi.org/10.13039/501100000781
UNSPECIFIEDSwedish State Support for Clinical ResearchUNSPECIFIED
ALFGBG-720931Vetenskapsrådethttp://dx.doi.org/10.13039/501100004359
201809-2016862Alzheimer's Drug Discovery Foundationhttps://www.alzdiscovery.org/
ADSF-21-831376-CAlzheimer's Associationhttp://dx.doi.org/10.13039/100000957
ADSF-21-831381-CAlzheimer's Associationhttp://dx.doi.org/10.13039/100000957
ADSF-21-831377-CAlzheimer's Associationhttp://dx.doi.org/10.13039/100000957
UNSPECIFIEDOlav Thon Stiftelsenhttps://olavthonstiftelsen.no/
UNSPECIFIEDErling Perssons Stiftelsehttps://www.erlingperssonsstiftelse.se/
FO2019-0228Hjarnfondenhttps://www.hjarnfonden.se/
860197 (MIRIADE)Horizon 2020 Framework Programmehttp://dx.doi.org/10.13039/100010661
UNSPECIFIEDUK Dementia Research Institutehttps://www.ucl.ac.uk/uk-dementia-research-institute/
2017-00915Vetenskapsrådethttp://dx.doi.org/10.13039/501100004359
RDAPB-201809-2016615)Alzheimer's Drug Discovery Foundationhttps://www.alzdiscovery.org/
AF-742881Alzheimerfondenhttp://dx.doi.org/10.13039/501100008599
FO2017-0243Hjarnfondenhttps://www.hjarnfonden.se/
ALFGBG-715986Vetenskapsrådethttp://dx.doi.org/10.13039/501100004359
JPND2019-466-236European Commissionhttp://dx.doi.org/10.13039/501100000780
1R01AG068398-01National Institutes of Healthhttp://dx.doi.org/10.13039/100000002
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