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Structure and stability of symptoms in first episode psychosis : a longitudinal network approach
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Griffiths, Siân Lowri, Leighton, Samuel P., Mallikarjun, Pavan Kumar, Blake, Georgina, Everard, Linda, Jones, Peter B., Fowler, David, Hodgekins, Joanne, Amos, Tim, Freemantle, Nick, Sharma, Vimal, Marshall, Max, McCrone, Paul, Singh, Swaran P., Birchwood, Max and Upthegrove, Rachel (2021) Structure and stability of symptoms in first episode psychosis : a longitudinal network approach. Translational Psychiatry, 11 (1). 567. doi:10.1038/s41398-021-01687-y ISSN 2158-3188.
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WRAP-structure-stability-symptoms-first-episode-psychosis-Singh-2021.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1274Kb) | Preview |
Official URL: https://doi.org/10.1038/s41398-021-01687-y
Abstract
Early psychosis is characterised by heterogeneity in illness trajectories, where outcomes remain poor for many. Understanding psychosis symptoms and their relation to illness outcomes, from a novel network perspective, may help to delineate psychopathology within early psychosis and identify pivotal targets for intervention. Using network modelling in first episode psychosis (FEP), this study aimed to identify: (a) key central and bridge symptoms most influential in symptom networks, and (b) examine the structure and stability of the networks at baseline and 12-month follow-up. Data on 1027 participants with FEP were taken from the National EDEN longitudinal study and used to create regularised partial correlation networks using the ‘EBICglasso’ algorithm for positive, negative, and depressive symptoms at baseline and at 12-months. Centrality and bridge estimations were computed using a permutation-based network comparison test. Depression featured as a central symptom in both the baseline and 12-month networks. Conceptual disorganisation, stereotyped thinking, along with hallucinations and suspiciousness featured as key bridge symptoms across the networks. The network comparison test revealed that the strength and bridge centralities did not differ significantly between the two networks (C = 0.096153; p = 0.22297). However, the network structure and connectedness differed significantly from baseline to follow-up (M = 0.16405, p = <0.0001; S = 0.74536, p = 0.02), with several associations between psychosis and depressive items differing significantly by 12 months. Depressive symptoms, in addition to symptoms of thought disturbance (e.g. conceptual disorganisation and stereotyped thinking), may be examples of important, under-recognized treatment targets in early psychosis, which may have the potential to lead to global symptom improvements and better recovery.
| Item Type: | Journal Article | |||||||||||||||
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| Subjects: | R Medicine > RC Internal medicine | |||||||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| SWORD Depositor: | Library Publications Router | |||||||||||||||
| Library of Congress Subject Headings (LCSH): | Psychoses | |||||||||||||||
| Journal or Publication Title: | Translational Psychiatry | |||||||||||||||
| Publisher: | Nature Publishing Group | |||||||||||||||
| ISSN: | 2158-3188 | |||||||||||||||
| Official Date: | 6 November 2021 | |||||||||||||||
| Dates: |
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| Volume: | 11 | |||||||||||||||
| Number: | 1 | |||||||||||||||
| Article Number: | 567 | |||||||||||||||
| DOI: | 10.1038/s41398-021-01687-y | |||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||
| Publication Status: | Published | |||||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||
| Date of first compliant deposit: | 8 November 2021 | |||||||||||||||
| Date of first compliant Open Access: | 9 November 2021 | |||||||||||||||
| RIOXX Funder/Project Grant: |
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