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Metabolic syndrome is associated with prostate enlargement : a systematic review, meta-analysis and meta-regression on patients with lower urinary tract symptom factors
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Omran, Asma, Leca, Bianca M., Ostarijas, Eduard, Graham, Natasha, Da Silva, Ana Sofia, Zaïr, Zoulikha M., Miras, Alexander D. , le Roux, Carel W., Vincent, Royce P., Cardozo, Linda and Dimitriadis, Georgios K. (2022) Metabolic syndrome is associated with prostate enlargement : a systematic review, meta-analysis and meta-regression on patients with lower urinary tract symptom factors. Therapeutic Advances in Endocrinology and Metabolism, 12 . doi:10.1177/20420188211066210 ISSN 2042-0188.
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Official URL: https://doi.org/10.1177/20420188211066210
Abstract
Background:
Metabolic syndrome (MetS) is defined by at least three of the following five criteria: blood pressure ⩾130/85 mmHg, fasting blood glucose ⩾5.6 mmol/l, triglycerides concentration ⩾1.7 mmol/l, waist circumference ⩾102 cm (for men), and high-density lipoprotein cholesterol concentration <1.03 mmol/l (for men). MetS has been associated with worse lower urinary tract symptoms (LUTS) and higher International Prostate Symptom questionnaire scores.
Materials and Methods:
MEDLINE, Cochrane, ClinicalTrials.gov, and SCOPUS were critically appraised for all peer-reviewed manuscripts that suitably fulfilled our protocol’s inclusion criteria established a priori. Meta-analytical and meta-regression calculations were performed in R using the Sidik–Jonkman and Hartung–Knapp random effects model and predefined covariates.
Results:
A total of 70 studies (n = 90,206) were included in qualitative synthesis. From these, 60 studies focused on MetS and LUTS: 44 reported positive correlations, 5 reported negative correlations, 11 reported no association, and 10 studies focused on MetS and total prostate volume (TPV). MetS positively correlated with moderate LUTS [odds ratio (OR) = 1.56, 95% confidence interval (CI) = 1.35–1.80], severe LUTS (OR = 2.35, 95% CI = 1.82–3.03), overactive bladder (OAB; OR = 3.2, 95% CI = 1.6–5.8), and nocturia severity (OR = 2.509, 95% CI = 1.571–4.007) at multivariate analysis. A total of 30 studies (n = 22,206) were included in meta-analysis; MetS was significantly associated with higher TPV (mean differences = 4.4450 ml, 95% CI = 2.0177–6.8723), but no significant predictive factors for effect sizes were discovered.
Conclusion:
Our meta-analysis demonstrates a significant association between the aggravating effects of MetS, which commonly coexists with obesity and benign prostate enlargement.
Item Type: | Journal Article | ||||||||
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Subjects: | R Medicine > RC Internal medicine | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||||||
Library of Congress Subject Headings (LCSH): | Urinary organs -- Diseases, Prostate -- Cancer -- Prognosis, Metabolic syndrome , Obesity | ||||||||
Journal or Publication Title: | Therapeutic Advances in Endocrinology and Metabolism | ||||||||
Publisher: | Sage Publications Ltd | ||||||||
ISSN: | 2042-0188 | ||||||||
Official Date: | 1 January 2022 | ||||||||
Dates: |
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Volume: | 12 | ||||||||
DOI: | 10.1177/20420188211066210 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Reuse Statement (publisher, data, author rights): | Posted ahead of print. Omran, Asma, Leca, Bianca M., Oštarijaš, Eduard, Graham, Natasha, Da Silva, Ana Sofia, Zaïr, Zoulikha M., Miras, Alexander D., le Roux, Carel W., Vincent, Royce P., Cardozo, Linda and Dimitriadis, Georgios K. (2021) R : Metabolic syndrome is associated with prostate enlargement : a systematic review, meta-analysis and meta-regression on patients with lower urinary tract symptom factors. Therapeutic Advances in Endocrinology and Metabolism . (In Press) ournal Volume Number and Issue Number) pp. xx-xx. Copyright © [year] (Copyright Holder). Reprinted by permission of SAGE Publications. DOI: [DOI] Users who receive access to an article through a repository are reminded that the article is protected by copyright and reuse is restricted to non-commercial and no derivative uses. | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 8 November 2021 | ||||||||
Date of first compliant Open Access: | 10 November 2021 | ||||||||
RIOXX Funder/Project Grant: |
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