UNSPECIFIED (1998) The Ser(447)-Ter mutation of the lipoprotein lipase gene relates to variability of serum lipid and lipoprotein levels in monozygotic twins. JOURNAL OF LIPID RESEARCH, 39 (2). pp. 437-441. ISSN 0022-2275

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Abstract

Studies on monozygotic twins support a role for genetic determinants of plasma lipid, lipoprotein, and apolipoprotein levels. Gene variants of the enzyme lipoprotein lipase have been shown to associate with dyslipidemia and coronary artery disease. We assessed the gene-environment interaction by investigating the relationship between the lipoprotein lipase gene and plasma lipid, lipoprotein, and apolipoprotein variability and levels among 54 male monozygotic twin pairs (aged 18-28 years). The Ser(447)-Ter mutation (C-->G transversion) was associated with significantly smaller within-pair differences in plasma high density lipoprotein-cholesterol (CG [n = 10] vs. CC [n = 44], 3.7 +/- 5.3 mg/dl vs. 6.4 +/- 5.2 mg/dl, P < 0.03) and total cholesterol (CG [n = 10] vs. CC [n = 44], 7.9 +/- 9.4 mg/dl vs. 15.8 +/- 12.7 mg/dl, P < 0.05), indicating attenuated variability in response to environmental stimuli. This observation of a restrictive variability gene effect further supports a role for the lipoprotein lipase gene in the genetic regulation of lipids and lipoproteins and suggests that the Ser(447)-Ter mutation exerts multiple effects. This study also raises the possibility of a genetically determined responsiveness to dyslipidemia therapies.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry
Journal or Publication Title:	JOURNAL OF LIPID RESEARCH
Publisher:	LIPID RESEARCH INC
ISSN:	0022-2275
Date:	February 1998
Volume:	39
Number:	2
Number of Pages:	5
Page Range:	pp. 437-441
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/16008

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