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Lack of replication for the myosin- 18B association with mathematical ability in independent cohorts
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Pettigrew, K. A., Fajutrao-Valles, S. F. , Moll, K., Northstone, K., Ring, S., Pennell, C., Wang, C., Leavett, R., Hayiou-Thomas, M. E., Thompson, Paul A., Simpson, N. H., Fisher, S. E., Whitehouse, A. J. O., Snowling, M. J., Newbury, D. F. and Paracchini, S. (2015) Lack of replication for the myosin- 18B association with mathematical ability in independent cohorts. Genes, Brain and Behavior, 14 (4). pp. 369-376. doi:10.1111/gbb.12213 ISSN 1601-1848.
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Official URL: https://doi.org/10.1111/gbb.12213
Abstract
Twin studies indicate that dyscalculia (or mathematical disability) is caused partly by a genetic component, which is yet to be understood at the molecular level. Recently, a coding variant (rs133885) in the myosin-18B gene was shown to be associated with mathematical abilities with a specific effect among children with dyslexia. This association represents one of the most significant genetic associations reported to date for mathematical abilities and the only one reaching genome-wide statistical significance. We conducted a replication study in different cohorts to assess the effect of rs133885 maths-related measures. The study was conducted primarily using the Avon Longitudinal Study of Parents and Children (ALSPAC), (Nā=ā3819). We tested additional cohorts including the York Cohort, the Specific Language Impairment Consortium (SLIC) cohort and the Raine Cohort, and stratified them for a definition of dyslexia whenever possible. We did not observe any associations between rs133885 in myosin-18B and mathematical abilities among individuals with dyslexia or in the general population. Our results suggest that the myosin-18B variant is unlikely to be a main factor contributing to mathematical abilities.
Item Type: | Journal Article | ||||||||
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Divisions: | Faculty of Social Sciences > Centre for Educational Development, Appraisal and Research (CEDAR) | ||||||||
Journal or Publication Title: | Genes, Brain and Behavior | ||||||||
Publisher: | Wiley-Blackwell Publishing Ltd. | ||||||||
ISSN: | 1601-1848 | ||||||||
Official Date: | April 2015 | ||||||||
Dates: |
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Volume: | 14 | ||||||||
Number: | 4 | ||||||||
Page Range: | pp. 369-376 | ||||||||
DOI: | 10.1111/gbb.12213 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) |
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