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Exploring relationships between micro-macroenvironment and colon cancer
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Tabuso, Maria (2020) Exploring relationships between micro-macroenvironment and colon cancer. MD thesis, University of Warwick.
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WRAP_Theses_Tabuso_2020.pdf - Submitted Version - Requires a PDF viewer. Download (4Mb) | Preview |
Official URL: http://webcat.warwick.ac.uk/record=b3714388~S15
Abstract
Colorectal cancer (CRC) is a multifactorial disease characterized by complex interplay between genetic and epigenetic alterations occurring in epithelial cells, surrounding microenvironmental stroma and macroenvironmental factors, including obesity and metabolic syndrome. The bidirectional cross-talk between cancer cells and stromal cells within the tumour microenvironment has been proposed as active contributor to carcinogenesis, cancer progression and metastasis. The main aims of this study are: (1) to analyse the differential expression profile of peritumour adipose tissue and distal adipose tissue; (2) to evaluate cross-talk between cancer cells and adipocytes; (3) to investigate associations between BMI categories, metabolic syndrome and CRC molecular profile.
Elucidating tumour micro-macroenvironment phenotype can lead to understanding molecular mechanisms underlying CRC and could lead to new therapies.
Item Type: | Thesis (MD) | ||||
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Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) | ||||
Library of Congress Subject Headings (LCSH): | Rectum -- Cancer -- Molecular aspects, Colon (Anatomy) -- Cancer -- Molecular aspects | ||||
Official Date: | 11 June 2020 | ||||
Dates: |
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Institution: | University of Warwick | ||||
Theses Department: | Warwick Medical School | ||||
Thesis Type: | MD | ||||
Publication Status: | Unpublished | ||||
Supervisor(s)/Advisor: | Arasaradnam, Ramesh P. ; Christian, Mark (Associate professor) | ||||
Format of File: | |||||
Extent: | 212 leaves : illustrations (some colour) | ||||
Language: | eng |
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