Successful ab initio prediction of the tertiary structure of NK-lysin using multiple sequences and recognized supersecondary structural motifs
UNSPECIFIED (1997) Successful ab initio prediction of the tertiary structure of NK-lysin using multiple sequences and recognized supersecondary structural motifs. PROTEINS-STRUCTURE FUNCTION AND GENETICS (Suppl. 1). pp. 185-191. ISSN 0887-3585Full text not available from this repository.
A simple approach to protein tertiary structure prediction is described, based on the assembly of recognized supersecondary structural fragments taken from highly resolved protein structures by using a simulated annealing algorithm, The results of blind-testing this method on CASP2 target T0042 (pig NK-lysin) are presented, The predicted structure had a Co root-mean-square deviation of only 6.2 Angstrom from the experimental structure (and less than 5.0 Angstrom over the first 66 residues), and clearly had the correct fold when judged by using a number of objective measures, Despite the significant degree of success in this case, there is clearly much more development required before predictions with the accuracy of a good homology model can be made with this kind of approach. (C) 1998 Wiley-Liss, Inc.
|Item Type:||Journal Article|
|Subjects:||Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
|Journal or Publication Title:||PROTEINS-STRUCTURE FUNCTION AND GENETICS|
|Number of Pages:||7|
|Page Range:||pp. 185-191|
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