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Successful ab initio prediction of the tertiary structure of NK-lysin using multiple sequences and recognized supersecondary structural motifs
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UNSPECIFIED (1997) Successful ab initio prediction of the tertiary structure of NK-lysin using multiple sequences and recognized supersecondary structural motifs. PROTEINS-STRUCTURE FUNCTION AND GENETICS (Suppl. 1). pp. 185-191. ISSN 0887-3585
Full text not available from this repository.Abstract
A simple approach to protein tertiary structure prediction is described, based on the assembly of recognized supersecondary structural fragments taken from highly resolved protein structures by using a simulated annealing algorithm, The results of blind-testing this method on CASP2 target T0042 (pig NK-lysin) are presented, The predicted structure had a Co root-mean-square deviation of only 6.2 Angstrom from the experimental structure (and less than 5.0 Angstrom over the first 66 residues), and clearly had the correct fold when judged by using a number of objective measures, Despite the significant degree of success in this case, there is clearly much more development required before predictions with the accuracy of a good homology model can be made with this kind of approach. (C) 1998 Wiley-Liss, Inc.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
| Journal or Publication Title: | PROTEINS-STRUCTURE FUNCTION AND GENETICS |
| Publisher: | WILEY-LISS |
| ISSN: | 0887-3585 |
| Date: | 1997 |
| Number: | Suppl. 1 |
| Number of Pages: | 7 |
| Page Range: | pp. 185-191 |
| Publication Status: | Published |
| URI: | http://wrap.warwick.ac.uk/id/eprint/16021 |
Data sourced from Thomson Reuters' Web of Knowledge
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