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Trends and intensity of Rhinovirus invasions in Kilifi, coastal Kenya, over a 12-year period, 2007–2018
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Morobe, John Mwita, Kamau, Everlyn, Murunga, Nickson, Gatua, Winfred, Luka, Martha M., Lewa, Clement, Cheruiyot, Robinson, Mutunga, Martin, Odundo, Calleb, Nokes, D. James and Agoti, Charles N. (2021) Trends and intensity of Rhinovirus invasions in Kilifi, coastal Kenya, over a 12-year period, 2007–2018. Open Forum Infectious Diseases, 8 (12). ofab571. doi:10.1093/ofid/ofab571 ISSN 2328-8957.
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WRAP-trends-intensity-Rhinovirus-invasions-Kilifi-Coastal-Kenya-over-a-twelve-year period-2007-2018-Nokes-2021.pdf - Accepted Version Embargoed item. Restricted access to Repository staff only - Requires a PDF viewer. Download (1280Kb) |
Official URL: http://dx.doi.org/10.1093/ofid/ofab571
Abstract
Background:
Rhinoviruses (RVs) are ubiquitous pathogens and the principal etiological agents of common cold. Despite the high frequency of RV infections, data describing their long-term epidemiological patterns in a defined population remain limited.
Methods:
Here, we analysed 1,070 VP4/VP2 genomic region sequences sampled at Kilifi County Hospital on the Kenya Coast. The samples were collected between 2007 and 2018 from hospitalised paediatric patients (< 60 months) with acute respiratory illness.
Results:
Of 7,231 children enrolled, RV was detected in 1,497 (20.7%) and VP4/VP2 sequences were recovered from 1,070 samples (71.5%). A total of 144 different RV types were identified (67 Rhinovirus A, 18 Rhinovirus B and 59 Rhinovirus C) and at any month, several types co-circulated with alternating predominance. Within types multiple genetically divergent variants were observed. Ongoing RV infections through time appeared to be a combination of (i) persistent types (observed up to seven consecutive months), (ii) reintroduced genetically distinct variants and (iii) new invasions (average of eight new types, annually).
Conclusion:
Sustained RV presence in the Kilifi community is mainly due to frequent invasion by new types and variants rather than continuous transmission of locally established types/variants.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QR Microbiology | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||
Library of Congress Subject Headings (LCSH): | Rhinoviruses , Rhinoviruses -- Epidemiology -- Kenya -- Kilifi | ||||||||
Journal or Publication Title: | Open Forum Infectious Diseases | ||||||||
Publisher: | Oxford University Press | ||||||||
ISSN: | 2328-8957 | ||||||||
Official Date: | December 2021 | ||||||||
Dates: |
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Volume: | 8 | ||||||||
Number: | 12 | ||||||||
Article Number: | ofab571 | ||||||||
DOI: | 10.1093/ofid/ofab571 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 18 November 2021 | ||||||||
Date of first compliant Open Access: | 18 November 2021 | ||||||||
RIOXX Funder/Project Grant: |
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