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Role of the cell cycle in collective cell dynamics

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Li, Jintao, Schnyder, Simon K., Turner, Matthew S. and Yamamoto, Ryoichi (2021) Role of the cell cycle in collective cell dynamics. Physical Review X, 11 (3). 031025. doi:10.1103/PhysRevX.11.031025

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Official URL: http://dx.doi.org/10.1103/PhysRevX.11.031025

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Abstract

Cells coexist together in colonies or as tissues. Their behavior is controlled by an interplay between intercellular forces and biochemical regulation. We develop a simple model of the cell cycle, the fundamental regulatory network controlling growth and division, and couple this to the physical forces arising within the cell collective. We analyze this model using both particle-based computer simulations and a continuum theory. We focus on 2D colonies confined in a channel. These develop moving growth fronts of dividing cells with quiescent cells in the interior. The profile and speed of these fronts are nontrivially related to the substrate friction and the cell-cycle parameters, providing a possible approach to measure such parameters in experiments.

Item Type: Journal Article
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history
Library of Congress Subject Headings (LCSH): Cell cycle, Biophysics -- Research, Interdisciplinary research
Journal or Publication Title: Physical Review X
Publisher: American Physical Society
ISSN: 2160-3308
Official Date: September 2021
Dates:
DateEvent
September 2021Published
30 July 2021Available
9 June 2021Accepted
Volume: 11
Number: 3
Article Number: 031025
DOI: 10.1103/PhysRevX.11.031025
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
20H05619[JSPS] Japan Society for the Promotion of Sciencehttp://dx.doi.org/10.13039/501100001691
20H00129[JSPS] Japan Society for the Promotion of Sciencehttp://dx.doi.org/10.13039/501100001691

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