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Role of the cell cycle in collective cell dynamics
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Li, Jintao, Schnyder, Simon K., Turner, Matthew S. and Yamamoto, Ryoichi (2021) Role of the cell cycle in collective cell dynamics. Physical Review X, 11 (3). 031025. doi:10.1103/PhysRevX.11.031025
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PhysRevX.11.031025.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (3776Kb) | Preview |
Official URL: http://dx.doi.org/10.1103/PhysRevX.11.031025
Abstract
Cells coexist together in colonies or as tissues. Their behavior is controlled by an interplay between intercellular forces and biochemical regulation. We develop a simple model of the cell cycle, the fundamental regulatory network controlling growth and division, and couple this to the physical forces arising within the cell collective. We analyze this model using both particle-based computer simulations and a continuum theory. We focus on 2D colonies confined in a channel. These develop moving growth fronts of dividing cells with quiescent cells in the interior. The profile and speed of these fronts are nontrivially related to the substrate friction and the cell-cycle parameters, providing a possible approach to measure such parameters in experiments.
| Item Type: | Journal Article | |||||||||
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| Subjects: | Q Science > Q Science (General) Q Science > QH Natural history |
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| Library of Congress Subject Headings (LCSH): | Cell cycle, Biophysics -- Research, Interdisciplinary research | |||||||||
| Journal or Publication Title: | Physical Review X | |||||||||
| Publisher: | American Physical Society | |||||||||
| ISSN: | 2160-3308 | |||||||||
| Official Date: | September 2021 | |||||||||
| Dates: |
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| Volume: | 11 | |||||||||
| Number: | 3 | |||||||||
| Article Number: | 031025 | |||||||||
| DOI: | 10.1103/PhysRevX.11.031025 | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | Published | |||||||||
| Access rights to Published version: | Open Access | |||||||||
| RIOXX Funder/Project Grant: |
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