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Thiolene- and polycaprolactone methacrylate-based Polymerized High Internal Phase Emulsion (PolyHIPE) scaffolds for tissue engineering
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Aldemir Dikici, Betül, Malayeri, Atra, Sherborne, Colin, Dikici, Serkan, Paterson, Thomas, Dew, Lindsey, Hatton, Paul, Ortega Asencio, Ilida, MacNeil, Sheila, Langford, Caitlin, Cameron, Neil R. and Claeyssens, Frederik (2021) Thiolene- and polycaprolactone methacrylate-based Polymerized High Internal Phase Emulsion (PolyHIPE) scaffolds for tissue engineering. Biomacromolecules . doi:10.1021/acs.biomac.1c01129 ISSN 1525-7797.
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Official URL: https://doi.org/10.1021/acs.biomac.1c01129
Abstract
Highly porous emulsion templated polymers (PolyHIPEs) provide a number of potential advantages in the fabrication of scaffolds for tissue engineering and regenerative medicine. Porosity enables cell ingrowth and nutrient diffusion within, as well as waste removal from, the scaffold. The properties offered by emulsion templating alone include the provision of high interconnected porosity, and, in combination with additive manufacturing, the opportunity to introduce controlled multiscale porosity to complex or custom structures. However, the majority of monomer systems reported for PolyHIPE preparation are unsuitable for clinical applications as they are nondegradable. Thiol-ene chemistry is a promising route to produce biodegradable photocurable PolyHIPEs for the fabrication of scaffolds using conventional or additive manufacturing methods; however, relatively little research has been reported on this approach. This study reports the groundwork to fabricate thiol- and polycaprolactone (PCL)-based PolyHIPE materials via a photoinitiated thiolene click reaction. Two different formulations, either three-arm PCL methacrylate (3PCLMA) or four-arm PCL methacrylate (4PCLMA) moieties, were used in the PolyHIPE formulation. Biocompatibility of the PolyHIPEs was investigated using human dermal fibroblasts (HDFs) and human osteosarcoma cell line (MG-63) by DNA quantification assay, and developed PolyHIPEs were shown to be capable of supporting cell attachment and viability.
Item Type: | Journal Article | ||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||||
SWORD Depositor: | Library Publications Router | ||||||
Journal or Publication Title: | Biomacromolecules | ||||||
Publisher: | American Chemical Society | ||||||
ISSN: | 1525-7797 | ||||||
Official Date: | 3 November 2021 | ||||||
Dates: |
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DOI: | 10.1021/acs.biomac.1c01129 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Restricted or Subscription Access |
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