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Tungsten disulfide nanotubes enhance flow-induced crystallization and radio-opacity of polylactide without adversely affecting in vitro toxicity
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Ramachandran, Karthik, Shao, Zixuan, Di Luccio, Tiziana, Shen, Bo, Bello, Edgar E. Ruiz, Tammaro, Loredana, Villani, Fulvia, Loffredo, Fausta, Borriello, Carmela, Di Benedetto, Francesca, Magee, Eimear, McNally, Tony and Kornfield, Julia A. (2021) Tungsten disulfide nanotubes enhance flow-induced crystallization and radio-opacity of polylactide without adversely affecting in vitro toxicity. Acta Biomaterialia, 138 . pp. 313-326. doi:10.1016/j.actbio.2021.11.005
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WRAP-Tungsten-disulfide-nanotubes-flow-induced-crystallization-radio-opacity-polylactide-toxicity-2021.pdf - Accepted Version Embargoed item. Restricted access to Repository staff only until 17 November 2022. Contact author directly, specifying your specific needs. - Requires a PDF viewer. Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. Download (1945Kb) |
Official URL: http://dx.doi.org/10.1016/j.actbio.2021.11.005
Abstract
Treatment of vascular disease, from peripheral ischemia to coronary heart disease (CHD), is poised for transformation with the introduction of transient implants designed to “scaffold” regeneration of blood vessels and ultimately leave nothing behind. Improved materials could expand the use of these devices. Here, we examine one of the leading polymers for bioresorbable scaffolds (BRS), polylactide (PLA), as the matrix of nanocomposites with tungsten disulfide (WS2) nanotubes (WSNT), which may provide mechanical reinforcement and enhance radio-opacity. We evaluate in vitro cytotoxicity using vascular cells, flow-induced crystallization and radio-opacity of PLA-WSNT nanocomposites at low WSNT concentration. A small amount of WSNT (0.1 wt%) can effectively promote oriented crystallization of PLA without compromising molecular weight. And radio-opacity improves significantly: as little as 0.5 to 1 wt% WSNT doubles the radio-opacity of PLA-WSNT relative to PLA at 17 keV. The results suggest that a single component, WSNT, has the potential to increase the strength of BRS to enable thinner devices and increase radio-opacity to improve intraoperative visualization. The in vitro toxicity results indicate that PLA-WSNT nanocomposites are worthy of investigation in vivo. Although substantial further preclinical studies are needed, PLA-WSNT nanocomposites may provide a complement of material properties that may improve BVS and expand the range of lesions that can be treated using transient implants.
| Item Type: | Journal Article | ||||||||||||||||||
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| Subjects: | R Medicine > RC Internal medicine T Technology > TP Chemical technology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Engineering > WMG (Formerly the Warwick Manufacturing Group) | ||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Cerebrovascular disease -- Treatment, Polylactic acid, Polymers, Cardiovascular system -- Diseases -- Prevention, Tissue scaffolds, Cardiovascular instruments, Implanted, Heart -- Surgery, Nanotechnology -- Research, Tungsten -- Thermal properties | ||||||||||||||||||
| Journal or Publication Title: | Acta Biomaterialia | ||||||||||||||||||
| Publisher: | Elsevier Science Ltd. | ||||||||||||||||||
| ISSN: | 1742-7061 | ||||||||||||||||||
| Official Date: | 15 January 2021 | ||||||||||||||||||
| Dates: |
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| Volume: | 138 | ||||||||||||||||||
| Page Range: | pp. 313-326 | ||||||||||||||||||
| DOI: | 10.1016/j.actbio.2021.11.005 | ||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||||||||||||
| Copyright Holders: | © 2021 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. | ||||||||||||||||||
| RIOXX Funder/Project Grant: |
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