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Comparison of large animal models for acute ischemic stroke : which model to use
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Taha, A., Bobi, J., Dammers, R., Dijkhuizen, R., Dreyer, A. Y., van Es, A., Ferrara, F., Gounis, M. J., Nitzsche, B., Platt, S., Stoffel, M. H., Volovici, V., del Zoppo, G. J., Duncker, D. J., Dippel, D. W. J., Boltze, Johannes and van Beusekom, H. M. M. (2022) Comparison of large animal models for acute ischemic stroke : which model to use. Stroke, 53 (4). pp. 1411-1422. doi:10.1161/STROKEAHA.121.036050 ISSN 0039-2499.
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Official URL: https://doi.org/10.1161/STROKEAHA.121.036050
Abstract
Translation of acute ischemic stroke research to the clinical setting remains limited over the last few decades with only one drug, recombinant tissue-type plasminogen activator, successfully completing the path from experimental study to clinical practice. To improve the selection of experimental treatments before testing in clinical studies, the use of large gyrencephalic animal models of acute ischemic stroke has been recommended. Currently, these models include, among others, dogs, swine, sheep, and nonhuman primates that closely emulate aspects of the human setting of brain ischemia and reperfusion. Species-specific characteristics, such as the cerebrovascular architecture or pathophysiology of thrombotic/ischemic processes, significantly influence the suitability of a model to address specific research questions. In this article, we review key characteristics of the main large animal models used in translational studies of acute ischemic stroke, regarding (1) anatomy and physiology of the cerebral vasculature, including brain morphology, coagulation characteristics, and immune function; (2) ischemic stroke modeling, including vessel occlusion approaches, reproducibility of infarct size, procedural complications, and functional outcome assessment; and (3) implementation aspects, including ethics, logistics, and costs. This review specifically aims to facilitate the selection of the appropriate large animal model for studies on acute ischemic stroke, based on specific research questions and large animal model characteristics.
| Item Type: | Journal Article | ||||||||||||
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| Subjects: | R Medicine > R Medicine (General) R Medicine > RC Internal medicine |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||||||
| Library of Congress Subject Headings (LCSH): | Cerebrovascular disease -- Animal models, Cerebral ischemia, Laboratory animals, Animal models in research, Diseases -- Animal models, Cerebrovascular disease -- Research -- Methodology | ||||||||||||
| Journal or Publication Title: | Stroke | ||||||||||||
| Publisher: | Lippincott Williams & Wilkins | ||||||||||||
| ISSN: | 0039-2499 | ||||||||||||
| Official Date: | April 2022 | ||||||||||||
| Dates: |
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| Volume: | 53 | ||||||||||||
| Number: | 4 | ||||||||||||
| Page Range: | pp. 1411-1422 | ||||||||||||
| DOI: | 10.1161/STROKEAHA.121.036050 | ||||||||||||
| Status: | Peer Reviewed | ||||||||||||
| Publication Status: | Published | ||||||||||||
| Reuse Statement (publisher, data, author rights): | "This is a non-final version of an article published in final form in Taha, A., Bobi, J., Dammers, R., Dijkhuizen, R., Dreyer, A. Y., van Es, A., Ferrara, F., Gounis, M. J., Nitzsche, B., Platt, S., Stoffel, M. H., Volovici, V., del Zoppo, G. J., Duncker, D. J., Dippel, D. W. J., Boltze, Johannes and van Beusekom, H. M. M. (2022) Comparison of large animal models for acute ischemic stroke : which model to use. Stroke . doi:10.1161/STROKEAHA.121.036050 (In Press) https://doi.org/10.1161/STROKEAHA.121.036050 | ||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||||||
| Copyright Holders: | © 2022 American Heart Association, Inc. | ||||||||||||
| Date of first compliant deposit: | 25 November 2021 | ||||||||||||
| Date of first compliant Open Access: | 15 August 2022 | ||||||||||||
| RIOXX Funder/Project Grant: |
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