The Library
Antibacterial, remineralising and matrix metalloproteinase inhibiting scandium-doped phosphate glasses for treatment of dental caries
Tools
Valappil, Sabeel P., Abou Neel, Ensanya A., Pickup, David M., Burden, Emily, Sahdev, Rohan, Miles, Emma J., Cooper, Lee, Ansari, Tahera I., Hanna, John V. and Higham, Susan M. (2022) Antibacterial, remineralising and matrix metalloproteinase inhibiting scandium-doped phosphate glasses for treatment of dental caries. Dental Materials, 38 (1). pp. 94-107. doi:10.1016/j.dental.2021.10.014 ISSN 0109-5641.
|
PDF
WRAP-antibacterial-remineralising-matrix-metalloproteinase-inhibiting-scandium-doped-phosphate-glasses-treatment-dental-caries-Hanna-2021.pdf - Accepted Version - Requires a PDF viewer. Available under License Creative Commons: Attribution-Noncommercial-Share Alike 4.0. Download (1240Kb) | Preview |
Official URL: http://dx.doi.org/10.1016/j.dental.2021.10.014
Abstract
Objectives:
Antibiotic resistance is increasingly a growing global threat. This study aimed to investigate the potential use of newly developed scandium-doped phosphate-based glasses (Sc-PBGs) as an antibacterial and anticariogenic agent through controlled release of Sc3+ ions.
Methods:
Sc-PBGs with various calcium and sodium oxide contents were produced and characterised using thermal and spectroscopic analysis. Degradation behaviour, ion release, antibacterial action against Streptococcus mutans, anti-matrix metalloproteinase-2 (MMP-2) activity, remineralisation potential and in vivo biocompatibility were also investigated.
Results:
The developed glass system showed linear Sc3+ ions release over time. The released Sc3+ shows statistically significant inhibition of S. mutans biofilm (1.2 log10 CFU reduction at 6 h) and matrix metalloproteinase-2 (MMP-2) activity, compared with Sc-free glass and positive control. When Sc-PBGs were mounted alongside enamel sections, subjected to acidic challenges, alternating hyper- and hypomineralisation layers consistent with periods of re- and demineralisation were observed demonstrating their potential remineralising action. Furthermore, Sc-PBGs produced a non-toxic response when implanted subcutaneously for 2 weeks in Sprague Dawley rats.
Significance:
Since Sc3+ ions might act on various enzymes essential to the biological mechanisms underlying caries, Sc-PBGs could be a promising therapeutic agent against cariogenic bacteria.
Item Type: | Journal Article | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Subjects: | Q Science > QD Chemistry Q Science > QR Microbiology R Medicine > R Medicine (General) R Medicine > RK Dentistry |
||||||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Physics | ||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Drug resistance in microorganisms , Dental ceramics, Ceramics in medicine, Dental ceramic metals, Glass in medicine , Fourier transform infrared spectroscopy, Dental caries , Dental caries -- Prevention | ||||||||||||||||||
Journal or Publication Title: | Dental Materials | ||||||||||||||||||
Publisher: | Elsevier | ||||||||||||||||||
ISSN: | 0109-5641 | ||||||||||||||||||
Official Date: | January 2022 | ||||||||||||||||||
Dates: |
|
||||||||||||||||||
Volume: | 38 | ||||||||||||||||||
Number: | 1 | ||||||||||||||||||
Page Range: | pp. 94-107 | ||||||||||||||||||
DOI: | 10.1016/j.dental.2021.10.014 | ||||||||||||||||||
Status: | Peer Reviewed | ||||||||||||||||||
Publication Status: | Published | ||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||||||||
Date of first compliant deposit: | 14 December 2021 | ||||||||||||||||||
Date of first compliant Open Access: | 22 November 2022 | ||||||||||||||||||
RIOXX Funder/Project Grant: |
|
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |
Downloads
Downloads per month over past year