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Proteolytic processing of ricin a chain is not required for cytotoxicity
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UNSPECIFIED (1997) Proteolytic processing of ricin a chain is not required for cytotoxicity. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 241 (3). pp. 617-621. ISSN 0006-291X
Full text not available from this repository.Abstract
[I-125]-labeled ricin A chain was endocytosed by macrophages and Vero cells either on its own or as part of the ricin holotoxin. Subsequently [I-125]-ricin A chain was recovered from intoxicated cells by immunoprecipitation or acetone precipitation. The recovered protein was shown to have the same electrophoretic mobility as the material supplied to the cells. These data challenge an earlier suggestion that limited intracellular processing of ricin A chain by proteolytic enzymes is required for maximal toxicity. (C) 1997 Academic Press.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
| Journal or Publication Title: | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS |
| Publisher: | ACADEMIC PRESS INC |
| ISSN: | 0006-291X |
| Date: | 29 December 1997 |
| Volume: | 241 |
| Number: | 3 |
| Number of Pages: | 5 |
| Page Range: | pp. 617-621 |
| Publication Status: | Published |
| URI: | http://wrap.warwick.ac.uk/id/eprint/16101 |
Data sourced from Thomson Reuters' Web of Knowledge
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