The Library
Proteolytic processing of ricin a chain is not required for cytotoxicity
Tools
UNSPECIFIED (1997) Proteolytic processing of ricin a chain is not required for cytotoxicity. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 241 (3). pp. 617-621. ISSN 0006-291X.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Abstract
[I-125]-labeled ricin A chain was endocytosed by macrophages and Vero cells either on its own or as part of the ricin holotoxin. Subsequently [I-125]-ricin A chain was recovered from intoxicated cells by immunoprecipitation or acetone precipitation. The recovered protein was shown to have the same electrophoretic mobility as the material supplied to the cells. These data challenge an earlier suggestion that limited intracellular processing of ricin A chain by proteolytic enzymes is required for maximal toxicity. (C) 1997 Academic Press.
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
||||
Journal or Publication Title: | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | ||||
Publisher: | ACADEMIC PRESS INC | ||||
ISSN: | 0006-291X | ||||
Official Date: | 29 December 1997 | ||||
Dates: |
|
||||
Volume: | 241 | ||||
Number: | 3 | ||||
Number of Pages: | 5 | ||||
Page Range: | pp. 617-621 | ||||
Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |